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| __NOTOC__
| | #REDIRECT [[Nicardipine#Drug Interactions]] |
| {{Nicardipine}}
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| {{CMG}}; {{AE}}:{{AK}}
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| '''''For patient information about Nicardipine, click [[Nicardipine (patient information)|here]].'''''
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| ==DRUG INTERACTIONS==
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| ===Beta-Blockers===
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| In most patients, Cardene I.V. Premixed Injection can safely be used concomitantly with beta blockers. However, titrate slowly when using Cardene I.V. Premixed Injection in combination with a beta-blocker in heart failure patients [see Warnings and Precautions (5.3)].
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| ===Cimetidine===
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| [[Cimetidine ]]has been shown to increase nicardipine plasma concentrations with oral nicardipine administration. Frequently monitor response in patients receiving both drugs. Data with other histamine-2 antagonists are not available.
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| ===Cyclosporine===
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| Concomitant administration of oral nicardipine and [[cyclosporine]] results in elevated plasma cyclosporine levels. Closely monitor plasma concentrations of cyclosporine during Cardene I.V. Premixed Injection administration, and reduce the dose of cyclosporine accordingly.
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| ===In Vitro Interaction===
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| The plasma protein binding of nicardipine was not altered when therapeutic concentrations of [[furosemide]], [[propranolol]], [[dipyridamole]], [[warfarin]], [[quinidine]], or [[naproxen]] were added to human plasma in vitro.<ref> {{cite web | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f8ef8420-01d2-11de-a455-0002a5d5c51b | title = CARDENE I.V. (nicardipine hydrochloride) injection, solution [EKR Therapeutics, Inc.] |accessdate = }}</ref>
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| ==References==
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| {{Reflist|2}}
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| {{FDA}}
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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