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| __NOTOC__
| | #REDIRECT [[Guanfacine#Warnings]] |
| {{Guanfacine}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Warnings and Precautions==
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| ===5.1 Hypotension, Bradycardia, and Syncope===
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| Treatment with INTUNIV® can cause dose-dependent decreases in blood pressure and heart rate. Decreases were less pronounced over time of treatment. Orthostatic [[hypotension]]and syncope have been reported [see Adverse Reactions (6.1)].
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| Measure heart rate and blood pressure prior to initiation of therapy, following dose increases, and periodically while on therapy. Use INTUNIV® with caution in patients with a history of [[hypotension]], heart block, [[bradycardia]], cardiovascular disease, or who have a history of syncope or may have a condition that predisposes them to [[syncope]], such as [[hypotension]], orthostatic [[hypotension]], [[bradycardia]], or [[dehydration]]. Use INTUNIV® with caution in patients treated concomitantly with antihypertensives or other drugs that can reduce blood pressure or heart rate or increase the risk of [[syncope]]. Advise patients to avoid becoming [[dehydrated]] or overheated.
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| ===5.2 Sedation and Somnolence===
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| Somnolence and sedation were commonly reported adverse reactions in clinical studies [see Adverse Reactions (6.1)]. Before using INTUNIV® with other centrally active [[depressants]](such as [[phenothiazines]], [[barbiturates]], or [[benzodiazepines]]), consider the potential for additive sedative effects. Caution patients against operating heavy equipment or driving until they know how they respond to treatment with INTUNIV®. Advise patients to avoid use with alcohol.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = INTUNIV (GUANFACINE) TABLET, EXTENDED RELEASE INTUNIV (GUANFACINE) KIT [SHIRE US MANUFACTURING INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b972af81-3a37-40be-9fe1-3ddf59852528#section-12.1 | publisher = | date = | accessdate = 25 February 2014 }}</ref>
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| ==References==
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| {{reflist|2}}
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| {{Antihypertensives and diuretics}}
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| {{Antihyperkinetics}}
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| {{Adrenergics}}
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| [[Category:Antihypertensive agents]]
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| [[Category:Guanidines]]
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| [[Category:Alpha-adrenergic agonists]]
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| [[Category:Acetamides]]
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| [[Category:Organochlorides]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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