WBR0442: Difference between revisions

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(Created page with "{{WBRQuestion |QuestionAuthor={{Rim}} |ExamType=USMLE Step 1 |MainCategory=Pharmacology |SubCategory=Cardiology |MainCategory=Pharmacology |SubCategory=Cardiology |MainCategor...")
 
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{{WBRQuestion
{{WBRQuestion
|QuestionAuthor={{Rim}}
|QuestionAuthor={{Rim}} {{Alison}}
|ExamType=USMLE Step 1
|ExamType=USMLE Step 1
|MainCategory=Pharmacology
|MainCategory=Pharmacology
Line 20: Line 20:
|MainCategory=Pharmacology
|MainCategory=Pharmacology
|SubCategory=Cardiology
|SubCategory=Cardiology
|Prompt=A researcher is assessing in an experiment using mice the difference between the intravenous (i.v.) and the oral forms of metoprolol.  He administers both drugs into mice and notes the following plasma concentrations of both medications in the graph shown below.  Which of the following equations best corresponds to the bioavailability (F) of the metoprolol in the oral form?
|Prompt=A researcher, assessing difference between the intravenous (i.v.) and the oral forms of metoprolol using mice, administers both drugs to the mice and notes the following plasma concentrations of the medications illustrated in the graph below.  Which of the following equations best corresponds to the bioavailability (F) of metoprolol in the oral form?


[[Image:WBR Bioavailability.png]]
[[Image:WBR Bioavailability.png]]
|Explanation=[[Bioavailability]] (F) is defined as the proportion of the total area under the plasma concentration-time curve (AUC).  The relative bioavailability of the oral form of a drug can be calculated using the following equation: F = (AUCoral / AUCi.v.) x (Dosei.v./Doseoral)
|Explanation=[[Bioavailability]] (F) is defined as the proportion of the total area under the plasma concentration-time curve (AUC).  The relative [[bioavailability]] of the oral form of a drug can be calculated using the following equation: F = (AUCoral / AUCi.v.) x (Dosei.v./Doseoral)


Educational Objective:
|EducationalObjectives=
Bioavailability = F = (AUCoral / AUCi.v.) x (Dosei.v./Doseoral)
Bioavailability can be calculated with the following equation: F = (AUCoral / AUCi.v.) x (Dosei.v./Doseoral)
|References= First Aid 2014 page 239


|AnswerA=F = (AUCoral / AUCi.v.) x (Dosei.v./Doseoral)
|AnswerA=F = (AUCoral / AUCi.v.) x (Dosei.v./Doseoral)
|AnswerAExp=Bioavailability can be calculated using the equation: F = (AUCoral / AUCi.v.) x (Dosei.v./Doseoral)
|AnswerAExp=Bioavailability can be calculated using the equation: F = (AUCoral / AUCi.v.) x (Dosei.v./Doseoral)
|AnswerB=(AUCoral / Doseoral ) x (AUCi.v. x  Dosei.v.)
|AnswerB=(AUCoral / Doseoral ) x (AUCi.v. x  Dosei.v.)
|AnswerBExp=The equation is not correct to calculate the bioavailability.
|AnswerBExp=This equation is not used to calculate bioavailability.
|AnswerC=(AUCi.v. / AUCoral) x (Doseoral x Dosei.v.)
|AnswerC=(AUCi.v. / AUCoral) x (Doseoral x Dosei.v.)
|AnswerCExp=The equation is not correct to calculate the bioavailability.
|AnswerCExp=This equation is not used to calculate bioavailability.
|AnswerD=(Doseoral x AUCoral) x (Dosei.v. x AUCi.v.)
|AnswerD=(Doseoral x AUCoral) x (Dosei.v. x AUCi.v.)
|AnswerDExp=The equation is not correct to calculate the bioavailability.
|AnswerDExp=This equation is not used to calculate bioavailability.
|AnswerE=(AUCoral + Doseoral) / (AUCi.v. + Dosei.v.)
|AnswerE=(AUCoral + Doseoral) / (AUCi.v. + Dosei.v.)
|AnswerEExp=The equation is not correct to calculate the bioavailability.
|AnswerEExp=This equation is not used to calculate bioavailability.
|RightAnswer=A
|RightAnswer=A
|WBRKeyword=Bioavailability, pharmacokinetics, pharmacodynamics, oral, intravenous
|WBRKeyword=Bioavailability, pharmacokinetics, pharmacodynamics, oral, intravenous, equation, formula, calculation
|Approved=No
|Approved=Yes
}}
}}

Revision as of 14:44, 23 July 2014
Author [[PageAuthor::Rim Halaby, M.D. [1] (Reviewed by Alison Leibowitz)]]
Exam Type ExamType::USMLE Step 1
Main Category MainCategory::Pharmacology
Sub Category SubCategory::Cardiology
Prompt [[Prompt::A researcher, assessing difference between the intravenous (i.v.) and the oral forms of metoprolol using mice, administers both drugs to the mice and notes the following plasma concentrations of the medications illustrated in the graph below. Which of the following equations best corresponds to the bioavailability (F) of metoprolol in the oral form?

]]

Answer A AnswerA::F = (AUCoral / AUCi.v.) x (Dosei.v./Doseoral)
Answer A Explanation AnswerAExp::Bioavailability can be calculated using the equation: F = (AUCoral / AUCi.v.) x (Dosei.v./Doseoral)
Answer B AnswerB::(AUCoral / Doseoral ) x (AUCi.v. x Dosei.v.)
Answer B Explanation AnswerBExp::This equation is not used to calculate bioavailability.
Answer C AnswerC::(AUCi.v. / AUCoral) x (Doseoral x Dosei.v.)
Answer C Explanation AnswerCExp::This equation is not used to calculate bioavailability.
Answer D AnswerD::(Doseoral x AUCoral) x (Dosei.v. x AUCi.v.)
Answer D Explanation AnswerDExp::This equation is not used to calculate bioavailability.
Answer E AnswerE::(AUCoral + Doseoral) / (AUCi.v. + Dosei.v.)
Answer E Explanation AnswerEExp::This equation is not used to calculate bioavailability.
Right Answer RightAnswer::A
Explanation [[Explanation::Bioavailability (F) is defined as the proportion of the total area under the plasma concentration-time curve (AUC). The relative bioavailability of the oral form of a drug can be calculated using the following equation: F = (AUCoral / AUCi.v.) x (Dosei.v./Doseoral)

Educational Objective: Bioavailability can be calculated with the following equation: F = (AUCoral / AUCi.v.) x (Dosei.v./Doseoral)
References: First Aid 2014 page 239]]

Approved Approved::Yes
Keyword WBRKeyword::Bioavailability, WBRKeyword::pharmacokinetics, WBRKeyword::pharmacodynamics, WBRKeyword::oral, WBRKeyword::intravenous, WBRKeyword::equation, WBRKeyword::formula, WBRKeyword::calculation
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