Trimazosin: Difference between revisions

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Trimazosin
Clinical data
ATC code	C02CA03 (WHO) ;
Identifiers
	IUPAC name (2-hydroxy-2-methylpropyl) 4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)piperazine-1-carboxylate;
CAS Number	53746-46-6 ;
PubChem CID	37264;
ChemSpider	34203 ;
UNII	31L760807H;
ChEMBL	ChEMBL513301 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C20H29N5O6
Molar mass	435.47 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC(O)(C)C)N3CCN(c1nc(N)c2c(n1)c(OC)c(OC)c(OC)c2)CC3;
	InChI InChI=1S/C20H29N5O6/c1-20(2,27)11-31-19(26)25-8-6-24(7-9-25)18-22-14-12(17(21)23-18)10-13(28-3)15(29-4)16(14)30-5/h10,27H,6-9,11H2,1-5H3,(H2,21,22,23) ; Key:YNZXWQJZEDLQEG-UHFFFAOYSA-N ;
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Revision as of 17:12, 23 July 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

Overview

Trimazosin is a sympatholytic drug.

It is an alpha blocker.^[1]

Hess, H. J.; 1972.

References

↑ van Kalken CK, van der Meulen J, Oe PL, Vriesendorp R, Donker AJ (1986). "Pharmacokinetics of trimazosin and its effects on blood pressure, renal function and proteinuria during short-term therapy of patients with impaired renal function and hypertension". Eur. J. Clin. Pharmacol. 31 (1): 63–8. doi:10.1007/BF00870988. PMID 3780829.

[pmid3780829-1] van Kalken CK, van der Meulen J, Oe PL, Vriesendorp R, Donker AJ (1986). "Pharmacokinetics of trimazosin and its effects on blood pressure, renal function and proteinuria during short-term therapy of patients with impaired renal function and hypertension". Eur. J. Clin. Pharmacol. 31 (1): 63–8. doi:10.1007/BF00870988. PMID 3780829.

[1]

@@ Line 1: / Line 1: @@
 {{Drugbox
-| IUPAC_name        =
+| Verifiedfields = changed
-| image             =
+| Watchedfields = changed
-| CAS_number        =
+| verifiedrevid = 448137147
-| ATC_prefix        = C02
+| IUPAC_name = (2-hydroxy-2-methylpropyl) 4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)piperazine-1-carboxylate
-| ATC_suffix        = CA03
+| image = Trimazosin.png
-| PubChem           = 37264
-| DrugBank          =
+<!--Clinical data-->
-| chemical_formula  = C20H29N5O6
+| tradename =
-| molecular_weight  = 435.47416
+| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
-| bioavailability   =
+| pregnancy_US = <!-- A / B            / C / D / X -->
-| protein_bound     =
+| pregnancy_category =
-| metabolism        =
+| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
-| elimination_half-life =
+| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
-| excretion         =
+| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
-| pregnancy_AU      =  <!-- A / B1 / B2 / B3 / C / D / X -->
+| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
-| pregnancy_US      =  <!-- A / B            / C / D / X -->
+| legal_status =
-| pregnancy_category=
+| routes_of_administration =
-| legal_AU =  <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
-| legal_CA =  <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
+<!--Pharmacokinetic data-->
-| legal_UK =  <!-- GSL, P, POM, CD, or Class A, B, C -->
+| bioavailability =
-| legal_US =  <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
+| protein_bound =
-| legal_status      =
+| metabolism =
-| routes_of_administration =
+| elimination_half-life =
+| excretion =
+<!--Identifiers-->
+| CAS_number_Ref = {{cascite|correct|??}}
+| CAS_number = 53746-46-6
+| ATC_prefix = C02
+| ATC_suffix = CA03
+| PubChem = 37264
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
+| DrugBank =
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = 31L760807H
+| ChEMBL_Ref = {{ebicite|changed|EBI}}
+| ChEMBL = 513301
+| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
+| ChemSpiderID      = 34203
+| smiles            = O=C(OCC(O)(C)C)N3CCN(c1nc(N)c2c(n1)c(OC)c(OC)c(OC)c2)CC3
+| InChI             = 1/C20H29N5O6/c1-20(2,27)11-31-19(26)25-8-6-24(7-9-25)18-22-14-12(17(21)23-18)10-13(28-3)15(29-4)16(14)30-5/h10,27H,6-9,11H2,1-5H3,(H2,21,22,23)
+| InChIKey          = YNZXWQJZEDLQEG-UHFFFAOYAG
+| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
+| StdInChI          = 1S/C20H29N5O6/c1-20(2,27)11-31-19(26)25-8-6-24(7-9-25)18-22-14-12(17(21)23-18)10-13(28-3)15(29-4)16(14)30-5/h10,27H,6-9,11H2,1-5H3,(H2,21,22,23)
+| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
+| StdInChIKey       = YNZXWQJZEDLQEG-UHFFFAOYSA-N
+<!--Chemical data-->
+| C=20 | H=29 | N=5 | O=6
+| molecular_weight = 435.47 g/mol
 }}
-{{CMG}}
+__NOTOC__
+{{SI}}
+{{CMG}}; {{AE}} {{KS}}
+==Overview==
+'''Trimazosin''' is a [[sympatholytic]] drug.
+It is an [[alpha blocker]].<ref name="pmid3780829">{{cite journal |author=van Kalken CK, van der Meulen J, Oe PL, Vriesendorp R, Donker AJ |title=Pharmacokinetics of trimazosin and its effects on blood pressure, renal function and proteinuria during short-term therapy of patients with impaired renal function and hypertension |journal=Eur. J. Clin. Pharmacol. |volume=31 |issue=1 |pages=63–8 |year=1986 |pmid=3780829 |doi= 10.1007/BF00870988|url=}}</ref>
+[[File:Trimazocin.png|500px]]
-'''Trimazosin''' is a [[sympatholytic]] drug.
+Hess, H. J.; 1972.
+==References==
+{{reflist}}
 {{Antihypertensives and diuretics}}
-[[Category:Drugs]]
+[[Category:Antihypertensive agents]]
-{{WH}}
+[[Category:Cardiovascular Drugs]]
-{{WS}}
+[[Category:Drug]]

v t e Antihypertensives (C02) and diuretics (C03)
Sympatholytic agents	Template:Navbox subgroup
Vasodilators	Diazoxide • hydrazinophthalazine (Hydralazine, Dihydralazine, Endralazine, Cadralazine) • Minoxidil • Nitroprusside • Phentolamine
Other antihypertensives	serotonin antagonist (Ketanserin) • endothelin receptor antagonist (Bosentan, Ambrisentan, Sitaxsentan) • MAOI (Pargyline) • THI (Metirosine)
Diuretics	Template:Navbox subgroup

Clinical data

ATC code	C02CA03 (WHO)
Identifiers
IUPAC name (2-hydroxy-2-methylpropyl) 4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)piperazine-1-carboxylate
CAS Number	53746-46-6^Y
PubChem CID	37264
ChemSpider	34203^N
UNII	31L760807H
ChEMBL	ChEMBL513301^N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₀H₂₉N₅O₆
Molar mass	435.47 g/mol
3D model (JSmol)	Interactive image
SMILES O=C(OCC(O)(C)C)N3CCN(c1nc(N)c2c(n1)c(OC)c(OC)c(OC)c2)CC3
InChI InChI=1S/C20H29N5O6/c1-20(2,27)11-31-19(26)25-8-6-24(7-9-25)18-22-14-12(17(21)23-18)10-13(28-3)15(29-4)16(14)30-5/h10,27H,6-9,11H2,1-5H3,(H2,21,22,23)^N Key:YNZXWQJZEDLQEG-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Trimazosin: Difference between revisions

Revision as of 17:12, 23 July 2014

Overview

References

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