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Created page with "{{WBRQuestion |QuestionAuthor={{Rim}} |ExamType=USMLE Step 1 |MainCategory=Pathology |SubCategory=Endocrine |MainCategory=Pathology |SubCategory=Endocrine |MainCategory=Pathol..."
 
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{{WBRQuestion
{{WBRQuestion
|QuestionAuthor={{Rim}}
|QuestionAuthor={{Rim}} {{Alison}}
|ExamType=USMLE Step 1
|ExamType=USMLE Step 1
|MainCategory=Pathology
|MainCategory=Pathology
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|MainCategory=Pathology
|MainCategory=Pathology
|SubCategory=Endocrine
|SubCategory=Endocrine
|Prompt=A 45 year old female patient who is previously healthy presents to her physician’s office complaining of severe diarrhea since several days.  The patient’s past medical history is also significant for recurrent kidney stones and parathyroidectomy.  Fasting gastrin level is elevated.  Endoscopy reveals multiple ulcers in the stomach, duodenum, and the jejunum.  Which of the following is the most likely additional finding in this patient?  
|Prompt=A 45-year-old female who presents to the physician’s office with complaints of severe diarrhea of several days duration.  The patient’s medical history is significant for recurrent kidney stones and parathyroidectomy.  Her fasting gastrin level is elevated and endoscopy reveals multiple ulcers in the stomach, duodenum, and jejunum.  Which of the following findings is the most likely present in this patient?  
|Explanation=[[Men I syndrome]] is characterized by [[parathyroid]] tumors, [[pituitary]] tumors that are usually [[prolactinoma]] or [[GH secreting tumors]], and pancreatic endocrine tumors, such as [[gastrinoma]], [[insulinoma]], [[VIPoma]], or [[glucagonoma]].   
|Explanation=[[Men I syndrome]] is characterized by [[parathyroid]] tumors, [[pituitary]] tumors, which are usually [[prolactinoma]] or [[GH secreting tumors]], and pancreatic endocrine tumors, such as [[gastrinoma]], [[insulinoma]], [[VIPoma]], or [[glucagonoma]].   


Educational Objective:
|EducationalObjectives= MEN I syndrome often manifests with pituitary tumors, parathyroid tumors, or pancreatic endocrine tumors.  
MEN I syndrome is characterized by pituitary tumor, parathyroid tumor, and pancreatic endocrine tumor.  


|AnswerA=Oral ganglioneuroma
|AnswerA=Oral ganglioneuroma
|AnswerAExp=Oral ganglioneuromatosis is seen in patients with MEN2B syndrome.
|AnswerAExp=Oral ganglioneuromatosis frequently occurs in patients with MEN2B syndrome.
|AnswerB=Pheochromocytoma
|AnswerB=Pheochromocytoma
|AnswerBExp=Pheochromocytoma can be found in MEN 2A and MEN 2B syndromes.
|AnswerBExp=Pheochromocytoma frequently occurs in MEN 2A and MEN 2B syndromes.
|AnswerC=Medullary thyroid cancer
|AnswerC=Medullary thyroid cancer
|AnswerCExp=Medullary thyroid cancer can be found in MEN 2A and MEN 2B syndromes.
|AnswerCExp=Medullary thyroid cancer frequently occurs in MEN 2A and MEN 2B syndromes.
|AnswerD=Prolactinoma
|AnswerD=Prolactinoma
|AnswerDExp=Prolactinoma, a pituitary tumor, can be found in MEN I syndrome.
|AnswerDExp=Prolactinoma, a pituitary tumor, frequently occurs in MEN I syndrome.
|AnswerE=Carcinoid tumor
|AnswerE=Carcinoid tumor
|AnswerEExp=Carcinoid tumor is an endocrine tumor but is not associated with any MEN syndrome.  
|AnswerEExp=Carcinoid tumor is an endocrine tumor, but is not frequently associated with MEN syndrome.  
|RightAnswer=D
|RightAnswer=D
|WBRKeyword=Prolactinoma, pheochromocytoma, gastrinoma, multiple, endocrine, neoplasia, MEN I, syndrome, Wermer’s, tumor
|WBRKeyword=Prolactinoma, pheochromocytoma, gastrinoma, neoplasia, MEN I, Wermer tumor, diarrhea, ulcers
|Approved=No
|Approved=Yes
}}
}}

Revision as of 17:40, 23 July 2014
Author [[PageAuthor::Rim Halaby, M.D. [1] (Reviewed by Alison Leibowitz)]]
Exam Type ExamType::USMLE Step 1
Main Category MainCategory::Pathology
Sub Category SubCategory::Endocrine
Prompt [[Prompt::A 45-year-old female who presents to the physician’s office with complaints of severe diarrhea of several days duration. The patient’s medical history is significant for recurrent kidney stones and parathyroidectomy. Her fasting gastrin level is elevated and endoscopy reveals multiple ulcers in the stomach, duodenum, and jejunum. Which of the following findings is the most likely present in this patient?]]
Answer A AnswerA::Oral ganglioneuroma
Answer A Explanation AnswerAExp::Oral ganglioneuromatosis frequently occurs in patients with MEN2B syndrome.
Answer B AnswerB::Pheochromocytoma
Answer B Explanation AnswerBExp::Pheochromocytoma frequently occurs in MEN 2A and MEN 2B syndromes.
Answer C AnswerC::Medullary thyroid cancer
Answer C Explanation AnswerCExp::Medullary thyroid cancer frequently occurs in MEN 2A and MEN 2B syndromes.
Answer D AnswerD::Prolactinoma
Answer D Explanation AnswerDExp::Prolactinoma, a pituitary tumor, frequently occurs in MEN I syndrome.
Answer E AnswerE::Carcinoid tumor
Answer E Explanation AnswerEExp::Carcinoid tumor is an endocrine tumor, but is not frequently associated with MEN syndrome.
Right Answer RightAnswer::D
Explanation [[Explanation::Men I syndrome is characterized by parathyroid tumors, pituitary tumors, which are usually prolactinoma or GH secreting tumors, and pancreatic endocrine tumors, such as gastrinoma, insulinoma, VIPoma, or glucagonoma.

Educational Objective: MEN I syndrome often manifests with pituitary tumors, parathyroid tumors, or pancreatic endocrine tumors.
References: ]]

Approved Approved::Yes
Keyword WBRKeyword::Prolactinoma, WBRKeyword::pheochromocytoma, WBRKeyword::gastrinoma, WBRKeyword::neoplasia, WBRKeyword::MEN I, WBRKeyword::Wermer tumor, WBRKeyword::diarrhea, WBRKeyword::ulcers
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