'''Disopyramide''' ([[International Nonproprietary Name|INN]], trade names '''Norpace''' and '''Rythmodan''') is an [[antiarrhythmic]] [[medication]] used in the treatment of Ventricular Tachycardia.<ref>Guyton, Arthur C., Hall, John E. (2006). Textbook of Medical Physiology (11th ed.). Philadelphia: Elsevier Saunders</ref> It is a sodium channel blocker and therefore classified as a Class 1a anti-arrhythmic agent.<ref>Rizos, I. I., et al. "Effects of Intravenous Disopyramide and Quinidine on Normal Myocardium and on the Characteristics of Arrhythmias: Intraindividual Comparison in Patients with Sustained Ventricular Tachycardia." European heart journal 8.2 (1987): 154-63. Biological Sciences. Web. 10 Feb. 2012</ref>’<ref>Kim, S. Y. SY, and N. L. NL Benowitz. "Poisoning due to Class IA Antiarrhythmic Drugs. Quinidine, Procainamide and Disopyramide." Drug safety : an international journal of medical toxicology and drug experience 5.6 (1990): 393-420. Biological Sciences; Environmental Science and Pollution Management. Web. 12 Feb. 2012.</ref> Disopyramide has a negative inotropic effect on the ventricular myocardium, significantly decreasing the contractility.<ref>Levites, R. R., and G. J. GJ Anderson. "Electrophysiological Effects of Disopyramide Phosphate during Experimental Myocardial Ischemia." American Heart Journal 98.3 (1979): 339-44. Biological Sciences. Web. 15 Feb. 2012.</ref>'<ref>Mathur, P. P. PP. "Cardiovascular Effects of a Newer Antiarrhythmic Agent, Disopyramide Phosphate." American Heart Journal 84.6 (1972): 764-70. Biological Sciences; Environmental Science and Pollution Management. Web. 15 Feb. 2012</ref> Disopyramide also has an [[anticholinergic]] effect on the heart which accounts for many adverse side effects. Disopyramide is available in both oral and intravenous forms, and has a low degree of toxicity.<ref>Mathur, P. P. PP. "Cardiovascular Effects of a Newer Antiarrhythmic Agent, Disopyramide Phosphate." American Heart Journal 84.6 (1972): 764-70. Biological Sciences; Environmental Science and Pollution Management. Web. 15 Feb. 2012</ref>
'''| [[Disopyramide how supplied storage and handling|How Supplied/Storage and Handling]]'''
'''| [[Disopyramide labels and packages|Labels and Packages]]'''
==Mechanism of Action==
Norpace (disopyramide phosphate) is a Type 1 antiarrhythmic drug (i.e., similar to procainamide and quinidine). In animal studies Norpace decreases the rate of diastolic depolarization (phase 4) in cells with augmented automaticity, decreases the upstroke velocity (phase 0) and increases the action potential duration of normal cardiac cells, decreases the disparity in refractoriness between infarcted and adjacent normally perfused myocardium, and has no effect on alpha- or beta-adrenergic receptors.
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Black Box Warning
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See full prescribing information for complete Boxed Warning.
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Disopyramide is a that is FDA approved for the {{{indicationType}}} of . There is a Black Box Warning for this drug as shown here. Common adverse reactions include .
Adult Indications and Dosage
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Off-Label Use and Dosage (Adult)
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There is limited information regarding Off-Label Guideline-Supported Use of Disopyramide in adult patients.
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There is limited information regarding Off-Label Non–Guideline-Supported Use of Disopyramide in adult patients.
Pediatric Indications and Dosage
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There is limited information regarding FDA-Labeled Use of Disopyramide in pediatric patients.
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There is limited information regarding Off-Label Guideline-Supported Use of Disopyramide in pediatric patients.
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There is limited information regarding Off-Label Non–Guideline-Supported Use of Disopyramide in pediatric patients.
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Clinical Trials Experience
There is limited information regarding Clinical Trial Experience of Disopyramide in the drug label.
Body as a Whole
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Postmarketing Experience
There is limited information regarding Postmarketing Experience of Disopyramide in the drug label.