Phentolamine

Phentolamine
Clinical data
Trade names	Regitine
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy; category	C (U.S.);
Routes of; administration	Usually IV or IM
ATC code	C04AB01 (WHO) V03AB36 (WHO);
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	19 minutes
Identifiers
	IUPAC name 3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol;
CAS Number	50-60-2 ;
PubChem CID	5775;
IUPHAR/BPS	502;
DrugBank	DB00692 ;
ChemSpider	5571 ;
UNII	Z468598HBV;
KEGG	D08362 ;
ChEBI	CHEBI:8081 ;
ChEMBL	ChEMBL597 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C17H19N3O
Molar mass	281.352 g/mol
3D model (JSmol)	Interactive image;
	SMILES Oc3cc(N(c1ccc(cc1)C)CC/2=N/CCN\2)ccc3;
	InChI InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19) ; Key:MRBDMNSDAVCSSF-UHFFFAOYSA-N ;
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Phentolamine
	Black Box Warning
	Adult Indications & Dosage
	Pediatric Indications & Dosage
	Contraindications
	Warnings & Precautions
	Adverse Reactions
	Drug Interactions
	Use in Specific Populations
	Administration & Monitoring
	Overdosage
	Pharmacology
	Clinical Studies
	How Supplied
	Images
	Patient Counseling Information
	Precautions with Alcohol
	Brand Names
	Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gerald Chi

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Black Box Warning

Title

See full prescribing information for complete Boxed Warning.

ConditionName:

Content

Overview

Phentolamine is a that is FDA approved for the {{{indicationType}}} of . There is a Black Box Warning for this drug as shown here. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition1

Dosing Information

Dosage

Condition2

Dosing Information

Dosage

Condition3

Dosing Information

Dosage

Condition4

Dosing Information

Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1

Developed by:

Class of Recommendation:

Strength of Evidence:

Dosing Information

Dosage

Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Phentolamine in adult patients.

Non–Guideline-Supported Use

Condition1

Dosing Information

Dosage

Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Phentolamine in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1

Dosing Information

Dosage

Condition2

There is limited information regarding FDA-Labeled Use of Phentolamine in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1

Developed by:

Class of Recommendation:

Strength of Evidence:

Dosing Information

Dosage

Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Phentolamine in pediatric patients.

Non–Guideline-Supported Use

Condition1

Dosing Information

Dosage

Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Phentolamine in pediatric patients.

Contraindications

Condition1

Warnings

Title

See full prescribing information for complete Boxed Warning.

ConditionName:

Content

Description

Precautions

Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Phentolamine in the drug label.

Body as a Whole

Cardiovascular

Digestive

Endocrine

Hematologic and Lymphatic

Metabolic and Nutritional

Musculoskeletal

Neurologic

Respiratory

Skin and Hypersensitivy Reactions

Special Senses

Urogenital

Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Phentolamine in the drug label.

Body as a Whole

Cardiovascular

Digestive

Endocrine

Hematologic and Lymphatic

Metabolic and Nutritional

Musculoskeletal

Neurologic

Respiratory

Skin and Hypersensitivy Reactions

Special Senses

Urogenital

Miscellaneous

Drug Interactions

Drug

Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

Pregnancy Category

Pregnancy Category (AUS):

Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Phentolamine in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Phentolamine during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Phentolamine with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Phentolamine with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Phentolamine with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Phentolamine with respect to specific gender populations.

Race

There is no FDA guidance on the use of Phentolamine with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Phentolamine in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Phentolamine in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Phentolamine in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Phentolamine in patients who are immunocompromised.

Administration and Monitoring

Administration

Oral

Intravenous

Monitoring

There is limited information regarding Monitoring of Phentolamine in the drug label.

Description

IV Compatibility

There is limited information regarding IV Compatibility of Phentolamine in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

Description

Management

Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Phentolamine in the drug label.

Pharmacology

Mechanism of Action

Structure

This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Phentolamine in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Phentolamine in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Phentolamine in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Phentolamine in the drug label.

How Supplied

Storage

There is limited information regarding Phentolamine Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Phentolamine |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Phentolamine |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Phentolamine in the drug label.

Precautions with Alcohol

Alcohol-Phentolamine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Regitine®
Oraverse®^[1]

Look-Alike Drug Names

A® — B®^[2]

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

↑ "Oraverse (phentolamine mesylate)".
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[1] "Oraverse (phentolamine mesylate)".

[www.ismp.org-2] "http://www.ismp.org". External link in |title= (help)

[1]

[2]