Colestilan

Colestilan

Clinical data
Routes of administration	Oral
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name 2-(chloromethyl)oxirane; 2-methyl-1H-imidazole
CAS Number	95522-45-5
PubChem CID	65840
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C7H11ClN2O
Molar mass	174.62 g/mol
3D model (JSmol)	Interactive image
SMILES CC1=NC=CN1.C1C(O1)CCl

WikiDoc Resources for Colestilan
Articles
Most recent articles on Colestilan Most cited articles on Colestilan Review articles on Colestilan Articles on Colestilan in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Colestilan Images of Colestilan Photos of Colestilan Podcasts & MP3s on Colestilan Videos on Colestilan
Evidence Based Medicine
Cochrane Collaboration on Colestilan Bandolier on Colestilan TRIP on Colestilan
Clinical Trials
Ongoing Trials on Colestilan at Clinical Trials.gov Trial results on Colestilan Clinical Trials on Colestilan at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Colestilan NICE Guidance on Colestilan NHS PRODIGY Guidance FDA on Colestilan CDC on Colestilan
Books
Books on Colestilan
News
Colestilan in the news Be alerted to news on Colestilan News trends on Colestilan
Commentary
Blogs on Colestilan
Definitions
Definitions of Colestilan
Patient Resources / Community
Patient resources on Colestilan Discussion groups on Colestilan Patient Handouts on Colestilan Directions to Hospitals Treating Colestilan Risk calculators and risk factors for Colestilan
Healthcare Provider Resources
Symptoms of Colestilan Causes & Risk Factors for Colestilan Diagnostic studies for Colestilan Treatment of Colestilan
Continuing Medical Education (CME)
CME Programs on Colestilan
International
Colestilan en Espanol Colestilan en Francais
Business
Colestilan in the Marketplace Patents on Colestilan
Experimental / Informatics
List of terms related to Colestilan

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Colestilan (INN, trade name BindRen) is a medication that acts as a phosphate binder and bile acid sequestrant.

Clinical Use

Colestilan is used for the treatment of hyperphosphataemia (too high phosphate concentrations in the blood serum) in patients undergoing dialysis, including peritoneal dialysis.

Contraindications

Colestilan is contraindicated in patients with bowel obstruction.

Interactions

The substance can inhibit the resorption of other drugs, as well as fat soluble vitamins (A, D, E, K) and folate, from the gut. Resulting lower blood levels can be clinically problematic with immunosuppressant and antiepileptic drugs.

Adverse Effects

Adverse effects include gastrointestinal problems such as constipation, as well as vitamin and calcium deficiency. Vitamin K deficiency sometimes causes gastrointestinal bleeding.

Chemistry and Mechanism of Action

Colestilan is a cross-linked copolymer of 2-methylimidazole and epichlorohydrin and works as an anion exchanger resin with affinity to phosphate, bile acid anions and urate. It binds these anions in the gut and removes them from the enterohepatic circulation. Colestilan is not absorbed from the gut, but is excreted together with the bound anions.