Hepatitis B screening
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
High risk groups, such as : persons born in high or intermediate endemic areas; United States– born persons not vaccinated as infants whose parents were born in regions with high HBV endemicity; persons needing immunosuppressive therapy; patients with history of IV drugs history; among others should be tested for HBV infection.
Screening
Recommendations for Persons Who Should Be Tested for HBV Infection: AASLD Practice Guidelines 2009
The following groups should be tested for HBV infection:[1]
- Persons born in high or intermediate endemic areas
- United States– born persons not vaccinated as infants whose parents were born in regions with high HBV endemicity]
- Persons with chronically elevated aminotransferases
- Persons needing immunosuppressive therapy
- Men who have sex with men
- Persons with multiple sexual partners or history of sexually transmitted disease
- Inmates of correctional facilities
- Persons who have ever used injecting drugs, dialysis patients, HIV or HCV infected individuals, pregnant women, and family members, household members, and sexual contacts of HBV infected persons.
- Testing for HBsAg and anti-HBs should be performed, and seronegative persons should be vaccinated. (Grade I Recommendation)}}
Recommendations for HCC Screening: AASLD Practice Guidelines 2009
The following groups should be screened with US examination every 6-12 months: (Grade II-2)[1]
- HBV carriers at high risk for HCC such as Asian men over 40 years and Asian women over 50 years of age
- Persons with cirrhosis
- Persons with a family history of HCC
- Africans over 20 years of age
- Any carrier over 40 years with persistent or intermittent ALT elevation and/or high HBV DNA level >2,000 IU/mL
For HBV carriers at high risk for HCC who are living in areas where US is not readily available, periodic screening with AFP should be considered. (Grade II-2)}}
References
- ↑ 1.0 1.1 Lok AS, McMahon BJ (2004). "[AASLD Practice Guidelines. Chronic hepatitis B: update of therapeutic guidelines]" (PDF). Romanian Journal of Gastroenterology. 13 (2): 150–4. PMID 15229781. Retrieved 2012-02-10. Unknown parameter
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