Prednisone
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];
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Overview
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Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
There is limited information regarding Prednisone FDA-Labeled Indications and Dosage (Adult) in the drug label.
Off-Label Use and Dosage (Adult)
Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Prednisone in adult patients.
Non–Guideline-Supported Use
There is limited information regarding Off-Label Non–Guideline-Supported Use of Prednisone in adult patients.
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
There is limited information regarding Prednisone FDA-Labeled Indications and Dosage (Pediatric) in the drug label.
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Prednisone in pediatric patients.
Non–Guideline-Supported Use
There is limited information regarding Off-Label Non–Guideline-Supported Use of Prednisone in pediatric patients.
Contraindications
There is limited information regarding Prednisone Contraindications in the drug label.
Warnings
There is limited information regarding Prednisone Warnings' in the drug label.
Adverse Reactions
Clinical Trials Experience
Fluid and Electrolyte Disturbances
- Sodium retention
- Fluid retention
- Congestive heart failure in susceptible patients
- Potassium loss
- Hypokalemic alkalosis
- Hypertension
Musculoskeletal
- Muscle weakness
- Steroid myopathy
- Loss of muscle mass
- Osteoporosis
- Vertebral compression fractures
- Aseptic necrosis of femoral and humeral heads
- Pathologic fracture of long bones
Gastrointestinal
- Peptic ulcer with possible perforation and hemorrhage
- Pancreatitis
- Abdominal distention
- Ulcerative esophagitis
Dermatologic
- Impaired wound healing
- Thin fragile skin
- Petechiae and ecchymoses
- Facial erythema
- Increased sweating
- May suppress reactions to skin tests
Metabolic
- Negative nitrogen balance due to protein catabolism
Neurological
- Increased intracranial pressure with papilledema (pseudo-tumor cerebri) usually after treatment
- Convulsions
- Vertigo
- Headache
Endocrine
- Menstrual irregularities
- Development of Cushingoid state
- Secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery or illness
- Suppression of growth in children
- Decreased carbohydrate tolerance
- Manifestations of latent diabetes melliltus
- Increased requirements for insulin or oral hypoglycemic agents in diabetics
Ophthalmic
- Posterior subcapsular cataracts
- Increased intraocular pressure
- Glaucoma
- Exophthalmos
Additional Reactions
- Urticaria and other allergic, anaphylactic or hypersensitivity reactions.
Postmarketing Experience
There is limited information regarding Prednisone Postmarketing Experience in the drug label.
Drug Interactions
There is limited information regarding Prednisone Drug Interactions in the drug label.
Use in Specific Populations
Pregnancy
Pregnancy Category (FDA):
There is no FDA guidance on usage of Prednisone in women who are pregnant.
Pregnancy Category (AUS):
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Prednisone in women who are pregnant.
Labor and Delivery
There is no FDA guidance on use of Prednisone during labor and delivery.
Nursing Mothers
There is no FDA guidance on the use of Prednisone in women who are nursing.
Pediatric Use
There is no FDA guidance on the use of Prednisone in pediatric settings.
Geriatic Use
There is no FDA guidance on the use of Prednisone in geriatric settings.
Gender
There is no FDA guidance on the use of Prednisone with respect to specific gender populations.
Race
There is no FDA guidance on the use of Prednisone with respect to specific racial populations.
Renal Impairment
There is no FDA guidance on the use of Prednisone in patients with renal impairment.
Hepatic Impairment
There is no FDA guidance on the use of Prednisone in patients with hepatic impairment.
Females of Reproductive Potential and Males
There is no FDA guidance on the use of Prednisone in women of reproductive potentials and males.
Immunocompromised Patients
There is no FDA guidance one the use of Prednisone in patients who are immunocompromised.
Administration and Monitoring
Administration
There is limited information regarding Prednisone Administration in the drug label.
Monitoring
There is limited information regarding Prednisone Monitoring in the drug label.
IV Compatibility
There is limited information regarding the compatibility of Prednisone and IV administrations.
Overdosage
There is limited information regarding Prednisone overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.
Pharmacology
There is limited information regarding Prednisone Pharmacology in the drug label.
Mechanism of Action
There is limited information regarding Prednisone Mechanism of Action in the drug label.
Structure
There is limited information regarding Prednisone Structure in the drug label.
Pharmacodynamics
There is limited information regarding Prednisone Pharmacodynamics in the drug label.
Pharmacokinetics
There is limited information regarding Prednisone Pharmacokinetics in the drug label.
Nonclinical Toxicology
There is limited information regarding Prednisone Nonclinical Toxicology in the drug label.
Clinical Studies
There is limited information regarding Prednisone Clinical Studies in the drug label.
How Supplied
There is limited information regarding Prednisone How Supplied in the drug label.
Storage
There is limited information regarding Prednisone Storage in the drug label.
Images
Drug Images
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Package and Label Display Panel
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Patient Counseling Information
There is limited information regarding Prednisone Patient Counseling Information in the drug label.
Precautions with Alcohol
Alcohol-Prednisone interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
Brand Names
There is limited information regarding Prednisone Brand Names in the drug label.
Look-Alike Drug Names
There is limited information regarding Prednisone Look-Alike Drug Names in the drug label.
Drug Shortage Status
Price
References
The contents of this FDA label are provided by the National Library of Medicine.
Synonyms / Brand Names: Adasone, Ancortone, Apo-prednisone, Betapar, Bicortone, Cartancyl,Colisone, Cortan, Cortancyl, Cortidelt, Cotone, Dacorten, Dacortin, Decortancyl, Decortin, Decortisyl, Dekortin, Delcortin, Dellacort, Dellacort A, Delta Cortelan, Delta E, Deltacortene, Deltacortisone, Deltacortone, Deltasone, Deltison, Deltisona, Deltisone, Deltra, Di-Adreson, Diadreson, Econosone, Encorton, Encortone, Enkorton, Fernisone, Fiasone, Hostacortin, In-Sone, Incocortyl, Juvason, Lisacort, Me-Korti, Metacortandracin, Meticorten, Nisona, Nizon, Novoprednisone, Nurison, Orasone, Origen Prednisone, Panafcort, Panasol, Paracort, Parmenison, Pehacort, Precort, Predeltin, Prednicen-M, Prednicorm, Prednicort, Prednicot, Prednidib, Prednilonga, Prednison, Prednisone Intensol, Prednitone, Prednizon, Prednovister, Presone, Pronison, Rectodelt, Retrocortine, Servisone, Sone, Sterapred, Supercortil, Ultracorten, Ultracortene, Winpred, Wojtab, Zenadrid
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]
Dosing and Administration
Dosage of Prednisone should be individualized according to the severity of the disease and the response of the patient. For infants and children, the recommended dosage should be governed by the same considerations rather than strict adherence to the ratio indicated by age or body weight. The initial dosage of Prednisone may vary from 5 mg to 60 mg per day depending on the specific disease entity being treated. In situations of less severity lower doses will generally suffice, while in selected patients higher initial doses may be required.
FDA Package Insert Resources
Indications, Contraindications, Side Effects, Drug Interactions, etc.
Calculate Creatine Clearance
On line calculator of your patients Cr Cl by a variety of formulas.
Convert pounds to Kilograms
On line calculator of your patients weight in pounds to Kg for dosing estimates.
Publication Resources
Recent articles, WikiDoc State of the Art Review, Textbook Information
Trial Resources
Ongoing Trials, Trial Results
Guidelines & Evidence Based Medicine Resources
US National Guidelines, Cochrane Collaboration, etc.
Media Resources
Slides, Video, Images, MP3, Podcasts, etc.
Patient Resources
Discussion Groups, Handouts, Blogs, News, etc.
International Resources
en Español
FDA Package Insert Resources
Indications
Contraindications
Side Effects
Drug Interactions
Precautions
Instructions for Administration
How Supplied
Pharmacokinetics and Molecular Data
FDA on Prednisone
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Publication Resources
Most Recent Articles on Prednisone
Review Articles on Prednisone
Articles on Prednisone in N Eng J Med, Lancet, BMJ
WikiDoc State of the Art Review
Textbook Information on Prednisone
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Trial Resources
Ongoing Trials with Prednisone at Clinical Trials.gov
Trial Results with Prednisone
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Guidelines & Evidence Based Medicine Resources
US National Guidelines Clearinghouse on Prednisone
Cochrane Collaboration on Prednisone
Cost Effectiveness of Prednisone
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Media Resources
Powerpoint Slides on Prednisone
Images of Prednisone
Podcasts & MP3s on Prednisone
Videos on Prednisone
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Patient Resources
Patient Resources on Prednisone
Discussion Groups on Prednisone
Patient Handouts on Prednisone
Blogs on Prednisone
Prednisone in the News
Prednisone in the Marketplace
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International Resources
Prednisone en Español
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Adapted from the FDA Package Insert.