Wilms' tumor
| Wilms' tumor | |
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| ICD-10 | C64 |
| ICD-9 | 189.0 |
| ICD-O: | Template:ICDO |
| OMIM | 194070 607102 |
| DiseasesDB | 8896 |
| MeSH | D009396 |
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Wilms' tumor Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Wilms' tumor On the Web |
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American Roentgen Ray Society Images of Wilms' tumor |
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Steven C. Campbell, M.D., Ph.D.; Assistant Editor-in-Chief: Savni Satoskar
Synonyms and keywords: Nephroblastoma
Overview
Historical Perspective
Pathophysiology
Causes
Differentiating Wilms' tumor from other Diseases
Epidemiology and Demographics
Screening
Natural History, Complications and Prognosis
Diagnosis
Staging | History and Symptoms | Physical Examination | Laboratory Findings | X Ray | CT | MRI | Ultrasound | Other Diagnostic Studies
Treatment
There are two schools of thought as to the best therapy for Wilms' tumor.
The National Wilms' Tumor Study (NWTS) has been studying this tumor in the United States since 1969. This group recommends surgery as the primary therapy for Wilms' tumor. They have carried out extensive research on this tumor which has been used to guide therapy, as well as to classify tumors into high and low risk groups based on molecular features and to estimate prognosis. [1]
The International Society of Paediatric Oncology in Europe, on the other hand, recommends preoperative chemotherapy to downstage the tumor prior to surgery to reduce the risk of intraoperative rupture of the tumor and dissemination of the malignant cells. A 4 week period of preoperative chemotherapy decreases the risk of intraoperative rupture of the tumor.
Medical Therapy | Surgery | Cost-Effectiveness of Therapy | Future or Investigational Therapies
Case Studies
Related Chapters
External links
- List of additional resources compiled by the NIH
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