Almotriptan
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vignesh Ponnusamy, M.B.B.S. [2]
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Overview
Almotriptan is a 5HT1B/1D receptor agonist that is FDA approved for the {{{indicationType}}} of acute treatment of migraine attacks in adults with a history of migraine with or without aura and migraine headache pain in adolescents age 12 to 17 years with a history of migraine with or without aura, and who have migraine attacks usually lasting 4 hours or more. Common adverse reactions include dry mouth, paresthesia, dizziness, somnolence, headache, paresthesia, nausea and vomiting.
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
Migraine
- AXERT® (almotriptan malate) is indicated for the acute treatment of migraine attacks in patients with a history of migraine with or without aura.
- The recommended dose of AXERT® (almotriptan malate) in adults is 6.25 mg to 12.5 mg, with the 12.5 mg dose tending to be a more effective dose in adults. As individuals may vary in their response to different doses of AXERT®, the choice of dose should be made on an individual basis.
- If the headache is relieved after the initial AXERT® dose but returns, the dose may be repeated after 2 hours. The effectiveness of a second dose has not been established in placebo-controlled trials. The maximum daily dose should not exceed 25 mg. The safety of treating an average of more than four migraines in a 30-day period has not been established.
Off-Label Use and Dosage (Adult)
Guideline-Supported Use
Condition1
- Developed by:
- Class of Recommendation:
- Strength of Evidence:
- Dosing Information
- Dosage
Condition2
There is limited information regarding Off-Label Guideline-Supported Use of Almotriptan in adult patients.
Non–Guideline-Supported Use
Condition1
- Dosing Information
- Dosage
Condition2
There is limited information regarding Off-Label Non–Guideline-Supported Use of Almotriptan in adult patients.
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
Condition1
- Dosing Information
- Dosage
Condition2
There is limited information regarding FDA-Labeled Use of Almotriptan in pediatric patients.
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
Condition1
- Developed by:
- Class of Recommendation:
- Strength of Evidence:
- Dosing Information
- Dosage
Condition2
There is limited information regarding Off-Label Guideline-Supported Use of Almotriptan in pediatric patients.
Non–Guideline-Supported Use
Condition1
- Dosing Information
- Dosage
Condition2
There is limited information regarding Off-Label Non–Guideline-Supported Use of Almotriptan in pediatric patients.
Contraindications
- Condition1
Warnings
- Description
Precautions
- Description
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Clinical Trial Experience of Almotriptan in the drug label.
Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous
Postmarketing Experience
There is limited information regarding Postmarketing Experience of Almotriptan in the drug label.
Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous
Drug Interactions
- Drug
- Description
Use in Specific Populations
Pregnancy
- Pregnancy Category
- Australian Drug Evaluation Committee (ADEC) Pregnancy Category
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Almotriptan in women who are pregnant.
Labor and Delivery
There is no FDA guidance on use of Almotriptan during labor and delivery.
Nursing Mothers
There is no FDA guidance on the use of Almotriptan with respect to nursing mothers.
Pediatric Use
There is no FDA guidance on the use of Almotriptan with respect to pediatric patients.
Geriatic Use
There is no FDA guidance on the use of Almotriptan with respect to geriatric patients.
Gender
There is no FDA guidance on the use of Almotriptan with respect to specific gender populations.
Race
There is no FDA guidance on the use of Almotriptan with respect to specific racial populations.
Renal Impairment
There is no FDA guidance on the use of Almotriptan in patients with renal impairment.
Hepatic Impairment
There is no FDA guidance on the use of Almotriptan in patients with hepatic impairment.
Females of Reproductive Potential and Males
There is no FDA guidance on the use of Almotriptan in women of reproductive potentials and males.
Immunocompromised Patients
There is no FDA guidance one the use of Almotriptan in patients who are immunocompromised.
Administration and Monitoring
Administration
- Oral
- Intravenous
Monitoring
There is limited information regarding Monitoring of Almotriptan in the drug label.
- Description
IV Compatibility
There is limited information regarding IV Compatibility of Almotriptan in the drug label.
Overdosage
Acute Overdose
Signs and Symptoms
- Description
Management
- Description
Chronic Overdose
There is limited information regarding Chronic Overdose of Almotriptan in the drug label.
Pharmacology
There is limited information regarding Almotriptan Pharmacology in the drug label.
Mechanism of Action
Structure
This image is provided by the National Library of Medicine.
Pharmacodynamics
There is limited information regarding Pharmacodynamics of Almotriptan in the drug label.
Pharmacokinetics
There is limited information regarding Pharmacokinetics of Almotriptan in the drug label.
Nonclinical Toxicology
There is limited information regarding Nonclinical Toxicology of Almotriptan in the drug label.
Clinical Studies
There is limited information regarding Clinical Studies of Almotriptan in the drug label.
How Supplied
Storage
There is limited information regarding Almotriptan Storage in the drug label.
Images
Drug Images
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Package and Label Display Panel
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Patient Counseling Information
There is limited information regarding Patient Counseling Information of Almotriptan in the drug label.
Precautions with Alcohol
- Alcohol-Almotriptan interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
Brand Names
- ®[1]
Look-Alike Drug Names
- A® — B®[2]
Drug Shortage Status
Price
References
The contents of this FDA label are provided by the National Library of Medicine.
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