Psoriasis causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Psoriasis is caused due to complex interactions between the genetics, immune system and environmental factors.

Causes

Common Causes

Genetics

• The human genome has at least nine different loci , which lead to the development of psoriasis (PSORS1-9).
• PSORS-1, a part of the major histocompatibility complex (MHC) on chromosome 6p2, is the major genetic determinant of psoriasis, and is responsible for up to fifty percent of genetic susceptibility to the disease.

Immune system

• Both innate and adaptive immunity is involved in the development of psoriasis.