Anaplastic large cell lymphoma, ALK positive
Template:DiseaseDisorder infobox Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alberto Plate [2]
Synonyms and keywords:
Overview
The Anaplastic large cell lymphoma ALK-positive (Anaplastic Llymphoma Kinase) consist of CD30-positive T-cells with abundant cytoplasm and a pleomorphic nucleus (horseshoe-shaped nucleus). This ALK-positive lymphoma has a translocation in the ALK gene (T[2;5]), which will in turn, express the ALK protein[1].
Historical Perspective
Classification
Pathophysiology
Causes
Differential Diagnosis
Epidemiology and Demographics
This entity affects primarily young, male patients[2].
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Treatment
References
- ↑ Swerdlow, Steven (2008). WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon, France: International Agency for Research on Cancer. ISBN 9789283224310.
- ↑ Stein H, Foss HD, Dürkop H, Marafioti T, Delsol G, Pulford K; et al. (2000). "CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features". Blood. 96 (12): 3681–95. PMID 11090048.