Iproclozide

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Iproclozide
Clinical data
Routes of; administration	Oral
ATC code	N06AF06 (WHO) ;
Legal status
Legal status	In general: uncontrolled;
Identifiers
	IUPAC name 2-(4-chlorophenoxy)-N'-isopropyl-acetohydrazide;
CAS Number	3544-35-2;
PubChem CID	19063;
ChemSpider	17998 ;
UNII	1II9D6CB3J;
KEGG	D07338 ;
ChEMBL	ChEMBL91238 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C11H15ClN2O2
Molar mass	242.70 g/mol
3D model (JSmol)	Interactive image;
	SMILES Clc1ccc(OCC(=O)NNC(C)C)cc1;
	InChI InChI=1S/C11H15ClN2O2/c1-8(2)13-14-11(15)7-16-10-5-3-9(12)4-6-10/h3-6,8,13H,7H2,1-2H3,(H,14,15) ; Key:GGECDTUJZOXAAR-UHFFFAOYSA-N ;
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Iproclozide (trade names Sursum, Sinderesin) is an irreversible and selective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant, but has since been discontinued.^[1] It has been known to cause fulminant hepatitis and there have been at least three reported fatalities due to administration of the drug.^[2]^[3]

References

↑ Suerinck A, Suerinck E. (1966). "[Depressive states in a sanatorium milieu and monoamine oxidase inhibitors. (Therapeutic results by the combination of iproclozide and chlordiazepoxide). Apropos of 146 cases]". Journal de médecine de Lyon. 47 (96): 573–586. PMID 5930723.
↑ Pessayre D, de Saint-Louvent P, Degott C, Bernuau J, Rueff B, Benhamou JP. (1978). "Iproclozide fulminant hepatitis. Possible role of enzyme induction". Gastroenterology. 75 (3): 492–496. PMID 680506.
↑ Neil Kaplowitz, Laurie D. DeLeve (2003). Drug-induced liver disease. Informa Health Care. p. 455. ISBN 0-8247-0811-3. ISBN 9780824708115.

Template:Antidepressants Template:Anxiolytics

[pmid5930723-1] Suerinck A, Suerinck E. (1966). "[Depressive states in a sanatorium milieu and monoamine oxidase inhibitors. (Therapeutic results by the combination of iproclozide and chlordiazepoxide). Apropos of 146 cases]". Journal de médecine de Lyon. 47 (96): 573–586. PMID 5930723.

[pmid680506-2] Pessayre D, de Saint-Louvent P, Degott C, Bernuau J, Rueff B, Benhamou JP. (1978). "Iproclozide fulminant hepatitis. Possible role of enzyme induction". Gastroenterology. 75 (3): 492–496. PMID 680506.

[bookDrug-induced_liver_disease-3] Neil Kaplowitz, Laurie D. DeLeve (2003). Drug-induced liver disease. Informa Health Care. p. 455. ISBN 0-8247-0811-3. ISBN 9780824708115.

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[2]

[3]

Iproclozide

Overview

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Clinical data

Routes of administration	Oral
ATC code	N06AF06 (WHO)
Legal status
Legal status	In general: uncontrolled
Identifiers
IUPAC name 2-(4-chlorophenoxy)-N'-isopropyl-acetohydrazide
CAS Number	3544-35-2
PubChem CID	19063
ChemSpider	17998^Y
UNII	1II9D6CB3J
KEGG	D07338^Y
ChEMBL	ChEMBL91238^Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₁₁H₁₅ClN₂O₂
Molar mass	242.70 g/mol
3D model (JSmol)	Interactive image
SMILES Clc1ccc(OCC(=O)NNC(C)C)cc1
InChI InChI=1S/C11H15ClN2O2/c1-8(2)13-14-11(15)7-16-10-5-3-9(12)4-6-10/h3-6,8,13H,7H2,1-2H3,(H,14,15)^Y Key:GGECDTUJZOXAAR-UHFFFAOYSA-N^Y
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