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Overview
Chlorothiazide (oral suspension) is a {{{drugClass}}} that is FDA approved for the treatment of {{{indication}}}. Common adverse reactions include .
DIURIL is indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension.
Use in Pregnancy. Routine use of diuretics during normal pregnancy is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development of toxemia of pregnancy and there is no satisfactory evidence that they are useful in the treatment of toxemia.
Edema during pregnancy may arise from pathologic causes or from the physiologic and mechanical consequences of pregnancy. Thiazides are indicated in pregnancy when edema is due to pathologic causes, just as they are in the absence of pregnancy. Dependent edema in pregnancy, resulting from restriction of venous return by the gravid uterus, is properly treated through elevation of the lower extremities and use of support stockings. Use of diuretics to lower intravascular volume in this instance is illogical and unnecessary. During normal pregnancy there is hypervolemia which is not harmful to the fetus or the mother in the absence of cardiovascular disease. However, it may be associated with edema, rarely generalized edema. If such edema causes discomfort, increased recumbency will often provide relief. Rarely this edema may cause extreme discomfort which is not relieved by rest. In these instances, a short course of diuretic therapy may provide relief and be appropriate.
Off-Label Use and Dosage (Adult)
Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Chlorothiazide (oral suspension) in adult patients.
Non–Guideline-Supported Use
There is limited information regarding Off-Label Non–Guideline-Supported Use of Chlorothiazide (oral suspension) in adult patients.
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
There is limited information regarding FDA-Labeled Use of Chlorothiazide (oral suspension) in pediatric patients.
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Chlorothiazide (oral suspension) in pediatric patients.
Non–Guideline-Supported Use
There is limited information regarding Off-Label Non–Guideline-Supported Use of Chlorothiazide (oral suspension) in pediatric patients.
Hypersensitivity to this product or to other sulfonamide-derived drugs.
Warnings
Use with caution in severe renal disease. In patients with renal disease, thiazides may precipitate azotemia. Cumulative effects of the drug may develop in patients with impaired renal function.
Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.
Thiazides may add to or potentiate the action of other antihypertensive drugs.
Sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma.
Lithium generally should not be given with diuretics
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Clinical Trial Experience of Chlorothiazide (oral suspension) in the drug label.
Postmarketing Experience
There is limited information regarding Postmarketing Experience of Chlorothiazide (oral suspension) in the drug label.
Body as a Whole
Cardiovascular
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous
Drug Interactions
Use in Specific Populations
Pregnancy
Pregnancy Category (FDA):
There is no FDA guidance on usage of Chlorothiazide (oral suspension) in women who are pregnant.
Pregnancy Category (AUS):
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Chlorothiazide (oral suspension) in women who are pregnant.
Labor and Delivery
There is no FDA guidance on use of Chlorothiazide (oral suspension) during labor and delivery.
Nursing Mothers
There is no FDA guidance on the use of Chlorothiazide (oral suspension) with respect to nursing mothers.
Pediatric Use
There is no FDA guidance on the use of Chlorothiazide (oral suspension) with respect to pediatric patients.
Geriatic Use
There is no FDA guidance on the use of Chlorothiazide (oral suspension) with respect to geriatric patients.
Gender
There is no FDA guidance on the use of Chlorothiazide (oral suspension) with respect to specific gender populations.
Race
There is no FDA guidance on the use of Chlorothiazide (oral suspension) with respect to specific racial populations.
Renal Impairment
There is no FDA guidance on the use of Chlorothiazide (oral suspension) in patients with renal impairment.
Hepatic Impairment
There is no FDA guidance on the use of Chlorothiazide (oral suspension) in patients with hepatic impairment.
Females of Reproductive Potential and Males
There is no FDA guidance on the use of Chlorothiazide (oral suspension) in women of reproductive potentials and males.
Immunocompromised Patients
There is no FDA guidance one the use of Chlorothiazide (oral suspension) in patients who are immunocompromised.
Administration and Monitoring
Administration
Oral
Intravenous
Monitoring
There is limited information regarding Monitoring of Chlorothiazide (oral suspension) in the drug label.
Description
IV Compatibility
There is limited information regarding IV Compatibility of Chlorothiazide (oral suspension) in the drug label.
Overdosage
Acute Overdose
Signs and Symptoms
Description
Management
Description
Chronic Overdose
There is limited information regarding Chronic Overdose of Chlorothiazide (oral suspension) in the drug label.
Pharmacology
There is limited information regarding Chlorothiazide (oral suspension) Pharmacology in the drug label.
There is limited information regarding Patient Counseling Information of Chlorothiazide (oral suspension) in the drug label.
Precautions with Alcohol
Alcohol-Chlorothiazide (oral suspension) interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.