Itch historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Historical Perspective
Historically, the sensations of itch and pain have not been considered to be independent of each other until recently where it was found that itch has several features in common with pain but exhibits notable differences.[1]The physiological mechanisms of itch are currently poorly understood and this is mainly due to the lack of animal models of itch. Pruritic stimuli mostly create the same reactions as noxious stimuli in experimental animals, but humans are capable of discerning the distinct features of itch and pain. Therefore human studies have provided most of the information regarding the processing of pruritic stimuli.[2]
References
- ↑ Twycross, R., Greaves, M.W., Handwerker, H., Jones, E.A., Libretto, S.E., Szepietowski, J.C., Zylicz, Z. (2003). Itch: scratching more than the surface. Q J Med, 96, 7-26.
- ↑ Ward, L., Wright E., McMahon S.B. (1996). A comparison of the effects of noxious and innocuous counterstimuli on experimentally induced itch and pain. Pain, 64, 129-138.