Sandbox g60
Differential Diagnosis
DDx
[1][2][3][4][5][6][7]- Sarcoidosis
DDx
- Lymphocytic lymphoma
DDx
- Miliary tuberculosis
DDx
- Infectious mononucleosis
DDx
- Thoracic aortic aneurysm
DDx
- Substernal goiter
DDx
- Thymoma
DDx
- Actinomycosis
DDx
- Chronic lymphocytic leukemia
DDx
- Superior vena cava syndrome
DDx
- Unicentric Castleman disease
DDx
- Adult Still disease
DDx
- Small cell lung carcinoma
DDx
- Malignant histiocytosis
DDx
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Mahshid Mir, M.D. [2]
Differential Diagnosis | |
---|---|
DDx Alphabetic Order | |
A | B |
C | D |
E | F |
G | H |
I | J |
K | L |
M | N |
O | P |
Q | R |
S | T |
U | V |
W | X |
Y | Z |
Clinical manifestations
- mental nerve neuropathy
- alcohol intolerance
- dermatitis, exfoliative
- epitrochlear lymph node enlargement
- inguinal lymph node enlargement
- hepatomegaly
- liver mass
- superior vena cava obstruction
- inferior vena cava obstruction
- femoral lymph node enlargement
- popliteal lymph node enlargement
- Pemberton sign positive
- fever, Pel-Ebstein
- ascites, chylous
- axillary lymph node enlargement
- erythema multiforme
- erythema nodosum
- hepatosplenomegaly
- mesenteric lymph node enlargement
- paraplegia
- pruritus
- spinal cord compression
- spleen enlargement
- urinary tract obstruction
- generalized diffuse lymph node enlargement
- airway compression or obstruction
- cryptococcosis
- bone pain
- cervical lymph node enlargement
- fever, recurrent
- recurrent infection
- lymph node, fixed
- neck mass
- night sweats
- anergy
- supraclavicular lymph node enlargement
- sweating increase
- fever unknown origin
- fever, remittent
- painless lymphadenopathy
- regional lymph node enlargement
Laboratory abnormalities
- nucleated red cells
- hypogammaglobulinemia
- pancytopenia
- lymphocytes decreased
- granulomas on biopsy
Radiographic features
- retroperitoneal lymph node enlargement
- abdominal ultrasound, biliary tract dilatation
- bone lesion
- chest xray mediastinal mass, adenopathy, or widening
- chest xray mediastinal mass middle
- mediastinal lymph node enlargement
- Anterior mediastinal mass on chest radiograph
- gallium scan, increased uptake, abdomen
- ivory vertebra
- gallium scan increased uptake, mediastinum
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3] Mahshid Mir, M.D. [4]
Differential Diagnosis | |
---|---|
DDx Alphabetic Order | |
A | B |
C | D |
E | F |
G | H |
I | J |
K | L |
M | N |
O | P |
Q | R |
S | T |
U | V |
W | X |
Y | Z |
Clinical manifestations
Laboratory abnormalities
Radiographic features
Evidence of "SARCOIDOSIS" (COMMON)
The following clinical manifestations (if present) would support this disease:
- corneal deposit
- corneal opacity
- parotid gland swelling
- polyneuropathy
- cranial nerve paralysis
- airway compression or obstruction
- retinal granuloma
- erythema nodosum
- uveitis
- ankle pain
- facial paralysis
- salivary gland swelling
- splenomegaly, massive
- cryptococcosis
- generalized rash, papules (elevated, <0.5cm)
- iridocyclitis
- iritis
- cough, dry
- night sweats
- spleen enlargement
- uveitis, bilateral
- generalized diffuse lymph node enlargement
- polyarthritis
The following lab data (if present) would be useful in establishing the presence of the disease:
- heart conduction abnormality, electrocardiographic
- atrioventricular block
- hypercalcemia
- retroperitoneal lymph node enlargement
- pleural effusion, lymphocytes increased
- CXR lung cyst
- lymphocytes decreased
- chest xray interstitial infiltrate ( incl. reticulonodular )
- hypercalciuria
- alkaline phosphatase, mild-moderate elevation
- gallium scan increased uptake, mediastinum
- gallium scan increased uptake, lungs
- PFT's: restrictive defect
- PFT's: diffusion capacity decreased
- mediastinal lymph node enlargement
- bone marrow granulomas
- serum angiotensin-converting enzyme elevated
- vitamin D, 1,25-dihydroxy, increased
- chest xray mediastinal mass, adenopathy, or widening
- granulomas on biopsy
- chest xray hilar lymph node enlargement
Evidence of "LYMPHOCYTIC LYMPHOMA" (COMMON)
The following clinical manifestations (if present) would support this disease:
- mental nerve neuropathy
- dermatitis, exfoliative
- extremity paralysis, lower
- gout
- esophageal candidiasis
- abdominal mass
- biliary tract obstruction
- breast mass
- epitrochlear lymph node enlargement
- erythema multiforme
- erythema nodosum
- esophageal obstruction
- facial edema
- gastric obstruction
- thyroid nodule
- hepatosplenomegaly
- intestinal obstruction
- intussusception
- liver mass
- mesenteric lymph node enlargement
- mucous membrane bleeding
- night sweats
- paraplegia
- pruritus
- anergy
- spinal cord compression
- stool clay color
- stool color yellow
- superior vena cava obstruction
- supraclavicular lymph node enlargement
- testicular mass
- urinary tract obstruction
- inferior vena cava obstruction
- generalized diffuse lymph node enlargement
- splenomegaly, massive
- femoral lymph node enlargement
- popliteal lymph node enlargement
- airway compression or obstruction
- cryptococcosis
- recurrent infection
- lymph node, fixed
- neck mass
- spleen enlargement
- fever unknown origin
- regional lymph node enlargement
- painless lymphadenopathy
- cancer
- lymphoma
- non-Hodgkin lymphoma
The following lab data (if present) would be useful in establishing the presence of the disease:
- IVP bladder mass or abnormal shape
- hypercalcemia, extreme (>14 mg/dl)
- bone destruction
- kidney mass
- mediastinal lymph node enlargement
- prolonged bleeding time
- ESR markedly increased
- retroperitoneal lymph node enlargement
- hypogammaglobulinemia
- bone lesion
- pancytopenia
- lymphocytes decreased
- chest xray mediastinal mass, adenopathy, or widening
- chest xray mediastinal mass anterior
- pleural effusion, exudate
- bone marrow plasma cells increased
- cryoglobulinemia
- abdominal ultrasound, biliary tract dilatation
- pleural effusion, lymphocytes increased
- pleural effusion, chylous
- malignant ascites
- gallium scan increased uptake, mediastinum
- gallium scan, increased uptake, abdomen
- vitamin D, 1,25-dihydroxy, increased
The following clinical manifestations (if present) would support this disease:
- prison inmate
- retinal granuloma
- erythema nodosum
- Haiti
- immunosuppressive therapy
- weight loss, severe
- corticosteroid use
- chest pain, pleuritic
- dyspnea, progressive
- fever unknown origin
- retinitis
- tuberculosis exposure
The following lab data (if present) would be useful in establishing the presence of the disease:
- pancytopenia
- PPD positive
- nucleated red cells
- gallium scan, increased uptake, abdomen
- abdominal CT: multiple hypodense liver lesions
- bone marrow granulomas
- AFB smear positive
- chest xray multiple pulmonary nodules, non-calcified
- granulomas on biopsy
Evidence of "INFECTIOUS MONONUCLEOSIS" (COMMON) The following clinical manifestations (if present) would support this disease:
- optic neuritis
- epitrochlear lymph node enlargement
- periorbital edema
- pharyngeal petechia
- spleen enlargement
- spleen palpable
- tonsillitis
- abdominal tenderness, left upper quadrant
- axillary lymph node enlargement
- inguinal lymph node enlargement
- mesenteric lymph node enlargement
- pharyngeal exudate
- pharyngeal erythema
- spleen tenderness
- tonsillar exudate
- generalized diffuse lymph node enlargement
- cervical lymph node enlargement
- pharyngeal swelling
- sore throat
The following lab data (if present) would be useful in establishing the presence of the disease:
- SGPT (ALT), marked elevation
- SGPT (ALT), elevated
- lymphocytes increased
- atypical lymphocytes increased
- heterophile antibody positive
- monocytes, increased
- Epstein-Barr virus titre positive
Evidence of "THORACIC AORTIC ANEURYSM" (RARE)
The following clinical manifestations (if present) would support this disease:
- cocaine use
- Turner syndrome
- Pemberton sign positive
- marfan syndrome
- aortic valve regurgitation
- superior vena cava obstruction
- aortic dilation, ascending
The following lab data (if present) would be useful in establishing the presence of the disease:
- chest xray mediastinal mass middle
- chest xray mediastinal mass posterior
- mediastinal widening
- chest xray aorta prominent or enlarged
- chest xray mediastinal mass anterior
- chest xray mediastinal mass, adenopathy, or widening
Evidence of "SUBSTERNAL GOITER" (RARE)
The following clinical manifestations (if present) would support this disease:
- upper extremity edema
- chest mass
- neck mass
- thyroid enlargement
- tracheal compression
- Pemberton sign positive
The following lab data (if present) would be useful in establishing the presence of the disease:
- TSH elevated
- chest xray mediastinal mass, adenopathy, or widening
- chest xray mediastinal mass anterior
Evidence of "THYMOMA" (RARE)
The following clinical manifestations (if present) would support this disease:
- bulbar palsy
- facial candida infection
- facial cyanosis
- jugular venous distention
- mouth candida infection
- superior vena cava obstruction
- diplopia
- Pemberton sign positive
The following lab data (if present) would be useful in establishing the presence of the disease:
- pancytopenia
- antistriational antibodies
- chest xray mediastinal mass, adenopathy, or widening
- chest xray mediastinal mass anterior
Evidence of "ACTINOMYCOSIS" (RARE)
The following clinical manifestations (if present) would support this disease:
- tongue mass
- trismus
- pericardial constriction
- pharyngeal swelling
- pharyngeal tenderness
- abdominal fistula
- bronchial fistula
- empyema
- lung abscess
- abdominal mass, right lower quadrant
- chest wall suppuration
- gingival fistula
- chest wall fistula
- gingival swelling
- gingival tenderness
- jaw induration
- mandibular swelling
The following lab data (if present) would be useful in establishing the presence of the disease:
- echocardiogram: intracardiac mass
- hepatic cyst(s)
- mediastinal lymph node enlargement
- chest xray mediastinal mass, adenopathy, or widening
- Gram stain: branching Gram-positive bacilli
- sulfur granule
Evidence of "CHRONIC LYMPHOCYTIC LEUKEMIA" (RARE)
The following clinical manifestations (if present) would support this disease:
- skin infiltration
- sternal tenderness
- lymph node firmness
The following lab data (if present) would be useful in establishing the presence of the disease:
- hemolysis
- mediastinal lymph node enlargement
- prolonged bleeding time
- chest xray mediastinal mass, adenopathy, or widening
- monoclonal gammopathy
- cryoglobulinemia
- leukocytes, marked increase
- flow cytometry: clonal B-lymphocytes
- lymphocytes increased
The following findings (if present) would make this disease less likely:
- left shift
- metamyelocytes increased
Evidence of "SUPERIOR VENA CAVA SYNDROME" (RARE - Urgent action required) The following clinical manifestations (if present) would support this disease:
- stridor
- facial erythema
- forehead vein distention
- lymphoma
- tracheal displacement
- chest vein distention
- facial cyanosis
- collateral circulation increase
- conjunctival edema
- conjunctival vein distention
- upper extremity edema
- upper extremity erythema
- head edema
- jugular venous distention with inspiration
- lung tumor
- extremity cyanosis
- upper extremity vein distention
- facial edema
- neck edema
- jugular venous distention
- lung cancer
- upper extremity cyanosis
- facial vein distention
- superior vena cava obstruction
The following lab data (if present) would be useful in establishing the presence of the disease:
- mediastinal lymph node enlargement
- chest xray pulmonary nodule (< 4 cm), non-calcified
- chest xray mediastinal mass, adenopathy, or widening
The following findings (if present) would exclude this disease:
- hepatojugular reflux
Evidence of "UNICENTRIC CASTLEMAN DISEASE" (RARE)
- The following lab data (if present) would be useful in establishing the presence of the disease:
- mediastinal lymph node enlargement
- chest xray mediastinal mass, adenopathy, or widening
Evidence of "ADULT STILL DISEASE" (RARE)
The following clinical manifestations (if present) would support this disease:
- ankylosis
- hepatosplenomegaly
- weight loss, severe
- fever, recurrent
- night sweats
- wrist pain
- generalized diffuse lymph node enlargement
- fever unknown origin
- fever, remittent
- fever, high grade
- polyarticular
- rash, evanescent
The following lab data (if present) would be useful in establishing the presence of the disease:
- leukocytes, marked increase
- ESR markedly increased
- serum ferritin greatly increased
The following findings (if present) would make this disease less likely:
- monoarticular
The following findings (if present) would exclude this disease:
- asymptomatic
Evidence of "SMALL CELL LUNG CARCINOMA" (COMMON)
The following clinical manifestations (if present) would support this disease:
- acanthosis nigricans
- axillary lymph node enlargement
- axillary lymph node pain
- dysphagia
- esophageal obstruction
- heart tamponade
- pericardial effusion
- rib tenderness, lower
- tracheal displacement
- hoarseness
- digital clubbing
- airway compression or obstruction
- Pemberton sign positive
- palms, velvet
- Horner syndrome
- superior vena cava obstruction
- bone pain
- spinal cord compression
- supraclavicular lymph node enlargement
- intracranial metastatic tumor
- acute symmetrical peripheral neuropathy
- hemoptysis
- right supraclavicular lymph node enlargement
- tobacco smoking
The following lab data (if present) would be useful in establishing the presence of the disease:
- bone destruction
- chest xray unilateral diaphragm elevation
- chest xray pulmonary nodule (< 4 cm), non-calcified
- chest xray mediastinal mass, adenopathy, or widening
- pleural effusion
- pleural effusion, bloody
- chest xray pulmonary mass (>= 4 cm), non-calcified
- hyponatremia
- bone marrow tumor cells
- serum calcitonin, increased
- chest xray hilar lymph node enlargement
The following findings (if present) would make this disease less likely:
- chest xray normal
- chest CT (contrast enhanced) normal
Evidence of "MALIGNANT HISTIOCYTOSIS" (RARE)
The following clinical manifestations (if present) would support this disease:
- tendon xanthoma
- xanthoma
- tuberous xanthoma
- planar xanthoma
- palmar planar xanthoma
- hepatosplenomegaly
- spleen enlargement
- panniculitis
- generalized diffuse lymph node enlargement
The following lab data (if present) would be useful in establishing the presence of the disease:
- ESR markedly increased
- serum ferritin greatly increased
- ESR mildly or moderately increased
- C-reactive protein elevated
- ↑ Ferri, Fred (2011). Ferri's differential diagnosis: a practical guide to the differential diagnosis of symptoms, signs, and clinical disorders. Philadelphia, PA: Elsevier/Mosby. ISBN 978-0323076999.
- ↑ Siegenthaler, Walter (2007). Differential diagnosis in internal medicine: from symptom to diagnosis. Stuttgart New York: Thieme. ISBN 978-1588905512.
- ↑ Mesko, Dusan (2002). Differential diagnosis by laboratory medicine: a quick reference for physicians. Berlin New York: Springer-Verlag. ISBN 978-3540430575.
- ↑ Reeder and Felson's gamuts in radiology: comprehensive lists of roentgen differential diagnosis. Place of publication not identified: Springer. 2014. ISBN 978-1475781229.
- ↑ Burgener, Francis (2008). Differential diagnosis in conventional radiology. Stuttgart New York: Thieme. ISBN 978-1588902757.
- ↑ Gattuso, Paolo (2015). Differential diagnosis in surgical pathology. Philadelphia, PA: Saunders/Elsevier. ISBN 978-1455770137.
- ↑ "DXplain".