Merkel cell cancer other diagnostic studies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
On biopsy, Merkel cell cancer is characterized by the presence of neurosecretory granules within cytoplasmic extensions and positivity for cytokeratin-20 immunohistochemical staining.
Biopsy
- Skin biopsy is required for the diagnosis of Merkel cell cancer.
- The histopathological diagnosis of Merkel cell tumor is difficult, and the majority of cases with Merkel cell cancer are often misdiagnosed.
- Cytokeratin-20 immunohistochemical staining is required for the histopathological diagnosis of Merkel cell cancer.
- On biopsy, Merkel cell cancer is often characterized by the following findings:[1]
- Neurosecretory granules within cytoplasmic extensions
- Positive staining for cytokeratin-20 immunohistochemical assay
- ↑ Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF; et al. (2008). "Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features". J Am Acad Dermatol. 58 (3): 375–81. doi:10.1016/j.jaad.2007.11.020. PMC 2335370. PMID 18280333.