Langerhans cell histiocytosis medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Treatment

Treatment is guided by extent of disease.

• Solitary bone lesion may be amenable through excision or limited radiation. However systemic disease often require chemotherapy.
• Use of systemic steroid is common, singly or adjunct to chemotherapy. Local steroid cream is applied to skin lesions.
• Endocrine deficiency often require lifelong suppliment e.g. desmopressin for diabates insipidus which can be applied as nasal drop.
• Chemotherapeutic agents such as alkylating agents, antimetabolites, vinca alkaloids either singly or in combination can lead to complete remission in diffuse disease.