Linitis plastica laboratory tests
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Overview
Laboratory findings consistent with the diagnosis of linitis plastica include abnormal thickening of the submucosal layer of the gastric wall on an endoscopic ultrasound and histopathologic evidence of signet-ring cells and fibrous stroma on gastric biopsies.
Laboratory findings
- Complete blood count (CBC)
- Complete metabolic panel (CMP)
- Esophagogastroduodenoscopy with multiple deep biopsies
- Mucosa may look innocent or show superficial ulcerations as in gastritis.
- Histopathologic specimens show poorly differentiated, atypical signet ring cells diffusely infiltrating the stomach wall, submucosal fibrosis and thickening.[1][2]
- Upper gastrointestinal endoscopic ultrasound
- A very useful test that helps both in the diagnosis and to know the depth of the tumor invasion.
- A 10-20mm thickening of the submucosal layer is usually present.
- Chest x-ray
- To rule out metastasis
- CT and MRI of chest, abdomen and pelvis
- To know the local invasion and distant metastasis (included as part of staging the disease)
References
- ↑ Schauer, M; Peiper, M; Theisen, J; Knoefel, W (2011). "Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment". European Journal of Medical Research. 16 (1): 29. doi:10.1186/2047-783X-16-1-29. ISSN 2047-783X.
- ↑ Stomach cancer. Wikipedia. https://en.wikipedia.org/wiki/Stomach_cancer Accessed on November 19, 2015.