Renal cell carcinoma classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Renal cell carcinoma may be classified according to histologic appearance of the tumor into 6 subtypes: conventional (clear cell), papillary, chromophobe, oncocytoma, collecting duct, and unclassified.
Classification
The following tables classify renal cell carcinoma according to histologic appearance and differentiates sporadic from hereditary forms of renal cell carcinoma. Clear type (also called Conventional type) renal cell carcinoma is considered the most common type of renal carcinoma. The most common classification of renal cell carcinoma is based on the histopathological appearance of the tumor. There are currently six subtypes of renal cell carcinoma, most common of which are the conventional (also called clear cell) renal carcinoma, accounting for approximately 75% of all cases.[1] Renal cell carcinoma may also be clinically classified based on the staging of the tumor, as shown below.
Histologic Appearance
| Histologic Appearance | Incidence (%) |
| Conventional (Clear Cell) | 75 |
| Papillary | 12 |
| Chromophobe | 4 |
| Oncocytoma | 4 |
| Collecting Duct | < 1 |
| Unclassified | 3 - 5 |
More than 70% of renal cell carcinomas are clear cell carcinomas. Papillary carcinomas are the second most common renal cell carcinomas. The least common types of renal cell carcinomas are collecting-duct renal cell carcinomas, accounting for less than 1% of all cases.[1]
References
- ↑ 1.0 1.1 1.2 Cohen HT, McGovern FJ (2005). "Renal-cell carcinoma". N Engl J Med. 353 (23): 2477–90. doi:10.1056/NEJMra043172. PMID 16339096.
- ↑ Kovacs G, Akhtar M, Beckwith BJ, Bugert P, Cooper CS, Delahunt B; et al. (1997). "The Heidelberg classification of renal cell tumours". J Pathol. 183 (2): 131–3. doi:10.1002/(SICI)1096-9896(199710)183:2<131::AID-PATH931>3.0.CO;2-G. PMID 9390023.