Myelofibrosis natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Complications

Common complications of myelofibrosis include:

• Acute myelogenous leukemia
• Infections
• Bleeding
• Blood clots
• Hepatic failure

Prognosis

Myelofibrosis leads to progressive bone marrow failure. The mean survival is five years and causes of death include infection, bleeding, organ failure, portal hypertension, and leukemic transformation.

References

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