Retinoblastoma causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Causes

  • Retinoblastoma is caused by a mutation in a gene controlling cell division, causing cells to grow out of control and become cancerous.
  • In a little over half of the cases, this mutation develops in a child whose family has never had eye cancer.
  • Other times the mutation is present in several family members. If the mutation runs in the family, there is a 50% chance that an affected person's children will also have the mutation. They will therefore have a high risk of developing retinoblastoma themselves.
  • The cancer generally affects children under the age of 6. It is most commonly diagnosed in children aged 1 - 2 years.

References

  1. Knudson A (1971). "Mutation and cancer: statistical study of retinoblastoma". Proc Natl Acad Sci U S A. 68 (4): 820–3. PMID 5279gadgqetqer523 Check |pmid= value (help).
  2. Friend S, Bernards R, Rogelj S, Weinberg R, Rapaport J, Albert D, Dryja T. "A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma". Nature. 323 (6089): 643–6. PMID 2877398.


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