Non-Hodgkin lymphoma classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Non-Hodgkin lymphoma may be classified according to updated REAL/WHO classification into 2 groups: Non-Hodgkin lymphoma may be classified based on rate of growth into 2 Groups:low-grade or indolent lymphoma and high-grade or aggressive lymphoma.
Classification of Non-Hodgkin lymphoma
A. Updated REAL/WHO classification
- Non-Hodgkin lymphoma may be classified according to updated REAL/WHO classification into 2 groups:[1]
- B-cell neoplasms
- T-cell and putative NK-cell neoplasms
1. B-cell neoplasms
- Precursor B-cell neoplasm: precursor B-acute lymphoblastic leukemia/lymphoblastic lymphoma (LBL)
- Peripheral B-cell neoplasms
- B-cell CLL/small lymphocytic lymphoma
- B-cell pro lymphocytic leukemia
- Lymphoplasmacytic lymphoma/immunocytoma
- Mantle cell lymphoma
- Follicular lymphoma
- Extra nodal marginal zone B-cell lymphoma of mucosa-associated lymphatic tissue (MALT) type
- Nodal marginal zone B-cell lymphoma (± mono cytoid B-cells)
- Splenic marginal zone lymphoma (± villous lymphocytes)
- Hairy cell leukemia
- Plasmacytoma/plasma cell myeloma
- Diffuse large B-cell lymphoma
- Burkitt lymphoma
2. T-cell and putative NK-cell neoplasms
- Precursor T-cell neoplasm: precursor T-acute lymphoblastic leukemia/LBL
- Peripheral T-cell and NK-cell neoplasms
- T-cell CLL/prolymphocytic leukemia
- T-cell granular lymphocytic leukemia
- Mycosis fungoides/Sézary syndrome
- Peripheral T-cell lymphoma, not otherwise characterized
- Hepatosplenic gamma/delta T-cell lymphoma
- Subcutaneous panniculitis-like T-cell lymphoma
- Angio immunoblastic T-cell lymphoma
- Extranodal T-/NK-cell lymphoma, nasal type
- Enteropathy-type intestinal T-cell lymphoma
- Adult T-cell lymphoma/leukemia (human T-lymphotrophic virus [HTLV] 1+)
- Anaplastic large cell lymphoma, primary systemic type
- Anaplastic large cell lymphoma, primary cutaneous type
- Aggressive NK-cell leukemia
B. Classification based on rate of growth
- Non-Hodgkin lymphoma may be classified based on rate of growth into 2 Groups:[2]
- Low-grade or Indolent lymphoma
- High-grade or Aggressive lymphoma
| Grade | Description |
|---|---|
| Low-grade or Indolent lymphoma | Tend to grow very slowly, tend to widespread by the time they are diagnosed, often involving the bone marrow and spleen. Often treated only when symptoms appear. Can shrink or seem to disappear with treatment, but they tend to come back. Can change into more aggressive lymphomas. Have a fairly good prognosis. |
| High-grade or Aggressive lymphoma | Grow quickly and tend to spread to lymph nodes or other organs throughout the body. Cause symptoms and need treatment right away. Can frequently be successfully treated with intensive chemotherapy treatment. |
References
- ↑ National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/publications/pdq
- ↑ "Canadian Cancer Society Grades of non-Hodgkin lymphoma".