Glioma natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Common complications of glioma include brain herniation, coma, metastasis, and recurrence. The prognosis for glioma varies with the grade of tumor. The 1-year and 2-year survival rate of patients with malignant glioma is approximately 50% and 25%, respectively.
Complications
Common complications of glioma include:
- Brain herniation
- Coma
- Metastasis
- Recurrence
- Side effects of chemotherapy
- Side effects of radiation therapy
Prognosis
The prognosis for glioma varies with the grade of tumor: WHO grade 1 and WHO grade 4 have the most favorable and worst prognosis, respectively. The 1-year and 2-year survival rate of patients with malignant glioma is approximately 50% and 25%, respectively.
The prognosis for glioma may depend on other factors which include:[1]
- Tumor is in the brain or spinal cord
- Whether the tumor can be removed by surgery
- Whether the cancer has just been diagnosed or has recurred
- DNA methylation of the O6-methylguanine-DNA methyltransferase (MGMT) gene promoter
- Mutation of isocitrate dehydrogenase: IDH1 or IDH2 genes
- Codeletion of chromosomes 1p and 19q
References
- ↑ Prognostic factors of glioma. National Cancer Institute. http://www.cancer.gov/types/brain/patient/adult-brain-treatment-pdq