Burkitt's lymphoma medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive immunotherapy and stem cell transplantation may be required.
Medical Therapy
Chemotherapy
- Drug Regimen: (CODOX-M) Cyclophosphamide, AND Vincristine, AND Doxorubicin, AND Methotrexate
- Drug Regimen: (IVAC) Ifosfamide PLUS Mesna, AND Etoposide, AND Cytarabine
- Drug Regimen: (Hyper-CVAD) Cyclophosphamide, AND Vincristine, AND Doxorubicin, AND Dexamethasone, AND Methotrexate, AND Cytarabine
Biological therapy
- Monoclonal antibodies are a type of biological therapy that is effective in treating Burkitt's lymphoma
- Rituximab may be added to each of the above chemotherapy regimens
CNS prophylaxis
- There is a high risk that Burkitt's lymphoma will spread to the central nervous system (CNS)
- CNS prophylaxis may involve giving intrathecal chemotherapy high doses of systemic therapy, or both methods may be used
- Methotrexate and Cytarabine are the drugs used most often for CNS prophylaxis
Stem cell transplant
- A Stem cell transplant may be offered to some people with Burkitt's lymphoma if their lymphoma returns or relapses after treatment