Medulloblastoma classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Medulloblastoma may be classified into several subtypes based on WHO 2007 histological classification system (desmoplastic medulloblastoma, large cell medulloblastoma, anaplastic medulloblastoma, and medulloblastoma with extensive nodularity) and the molecular subtypes classification system (WNT subgroup, SHH subgroup, Group C, and Group D).[1][2][3][4]
Classification
WHO 2007 histological classification system | |||||||||||||||||||||||||||||||||||||||
Classic medulloblastoma | Variant medulloblastoma | ||||||||||||||||||||||||||||||||||||||
Desmoplastic medulloblastoma | Large cell medulloblastoma | Anaplastic medulloblastoma | Medulloblastoma with extensive nodularity | ||||||||||||||||||||||||||||||||||||
Genomic classification system | |||||||||||||||||||||||||||||||||||||||
WNT subgroup | Sonic hedgehog (SHH) subgroup | Group 3 | Group 4 | ||||||||||||||||||||||||||||||||||||
References
- ↑ Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A; et al. (2007). "The 2007 WHO classification of tumours of the central nervous system". Acta Neuropathol. 114 (2): 97–109. doi:10.1007/s00401-007-0243-4. PMC 1929165. PMID 17618441.
- ↑ Leary SE, Olson JM (2012) The molecular classification of medulloblastoma: driving the next generation clinical trials. Curr Opin Pediatr 24 (1):33-9. DOI:10.1097/MOP.0b013e32834ec106 PMID: 22189395
- ↑ Medulloblastoma. Librepathology(2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on September, 28th 2015
- ↑ Medulloblastoma. radiopaedia(2015) http://radiopaedia.org/articles/medulloblastoma Accessed on September, 28th 2015