Osteosarcoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]

Overview

Osteosarcomas may be classified into several subtypes based on differentiation, location within the bone, and histological variants.

Classification

Osteosarcoma may be classified according to the World Health Organization’s histologic classification of bone tumors into three groups:

Central (medullary) tumors:

• Conventional central osteosarcomas.
• Telangiectatic osteosarcomas.
• Intraosseous well-differentiated (low-grade) osteosarcomas.
• Small-cell osteosarcomas.

Surface (peripheral) tumors:

• Parosteal (juxtacortical) well-differentiated (low-grade) osteosarcomas.
• Periosteal osteosarcoma: Low-grade to intermediate-grade osteosarcomas.
• High-grade surface osteosarcomas.

Extraskeletal:

• Extraskeletal osteosarcomas.