Acoustic neuroma classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
[Disease name] may be classified into several subtypes based on [classification method 1], [classification method 2], and [classification method 3]. Acoustic neuroma may be classified based on MRI scan into three subtypes: entirely canalicular, intracranial extension without brainstem distortion, and intracranial extension with brain stem distortion. Based on microscopic histopathology, acoustic neuroma may be classified into four subtypes: conventional schwannoma, cellular schwannoma plexiform schwannoma, and melanotic schwannoma.[1]
Classification
Based on the MRI scan, acoustic neuromas can be classified into three subtypes:
- Entirely intracanalicular: The entire tumor is completely within the bony canal
- Intracranial extension without brain stem distortion: intracranial portion of the tumor is 1-2 cm.
- Intracranial extension with brain stem distortion: intracranial portion of the tumor is greater than 2 cm.
Based on microscopic histopathology, acoustic neuroma can be classified into four subtypes:[2]
- Conventional schwannoma: It is the most common schwannoma.
- Cellular schwannoma: It may mimic malignant peripheral nerve sheath tumor.
- Plexiform schwannoma: It may mimic malignant peripheral nerve sheath tumor if cellular- especially in childhood.
Plexiform schwannoma with high magnifaction - Melanotic schwannoma: It may be confused with melanoma.
Psammomatous melanotic schwannoma
It is associated with psammomatous form (psammomatous melanotic schwannoma) and with a heritable disorder (Carney complex). The Carney complex, also known as Carney syndrome, NAME syndrome and LAMB syndrome, is an autosomal dominant syndrome associated with endocrinopathy, endocrine and nonendocrine tumors, and spotty pigmentation of the skin including the following:[3]
- Cutaneous lentigines
- Myxomas (skin (subcutaneous), subcutanous, heart)
- Endocrine neoplasms
References
- ↑ "Libre Pathology schwannoma acoustic neuroma subtypes".
- ↑ Kurtkaya-Yapicier O, Scheithauer B, Woodruff JM (2003). "The pathobiologic spectrum of Schwannomas". Histol Histopathol. 18 (3): 925–34. PMID 12792904.
- ↑ "Libre Pathology schwannoma acoustic neuroma subtypes".