Zollinger-Ellison syndrome screening
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
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Zollinger-Ellison syndrome Microchapters |
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Differentiating Zollinger-Ellison syndrome from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Zollinger-Ellison syndrome screening On the Web |
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American Roentgen Ray Society Images of Zollinger-Ellison syndrome screening |
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Risk calculators and risk factors for Zollinger-Ellison syndrome screening |
Overview
There is insufficient evidence to recommend routine screening for Zollinger-Ellison syndrome.
Screening
- The single best screening test for Zollinger-Ellison syndrome (ZES) is by measuring fasting serum gastrin levels.
- At the time of the test, it is advised not to take gastric antisecretory medications.
- Serial multiple measurements on different days have to be performed because, fasting gastrin levels can fluctuate from day to day and can appear to be normal.
- Normal levels of serum gastrin in untreated ZES are extremely rare (<1%)
- Multiple endocrine neoplasia-type 1 (MEN 1) syndrome should be suspected if serum calcium levels are elevated.