Optic nerve glioma epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
There is no racial predilection to the optic nerve glioma.[1] Optic nerve gliomas affects girls and boys equally.
Epidemiology and Demographics
Optic nerve gliomas typically present in children, and often in the setting of NF1 (10-63%). In this setting, the tumors are often low grade and indolent. In adults, optic nerve gliomas do occur but are very rare and usually aggressive tumors. In such cases no association with NF1 has been found.[2] 5 % of all childhood brain tumors account for optic nerve gliomas. About 1% of all intracranial tumors are comprised of optic-nerve gliomas.[3] It is most common in children who have the genetic condition neurofibromatosis 1 (NF1).
Gender
Boys and girls are equally affected.
Age
The mean age of presentation of optic nerve glioma is 8.8 years. Most optic gliomas occur in children, are slow-growing and noncancerous and almost always occur before age 20. 90 percent of optic nerve gliomas are diagnosed before the age of 20. 75 percent of optic nerve gliomas are diagnosed before the age of 10, 50 percent before the age of 5 and 25 percent before the age of 18 months.[4] The mean age of presentation of optic nerve gliomas is 8.8 years.[2] The incidence of NF-1 among patients of optic nerve glioma is 10-70% and the incidence of optic nerve glioma in patients with NF-1 varies from 8 to 31 %.[5]
| Age of onset of optic nerve glioma | Percentage of optic nerve glioma diagnosed |
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90% |
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75% |
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50 |
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25 |
Race
There are no racial or ethnic groups that are at more risk than others of optic nerve gliomas.
References
- ↑ Optic nerve glioma. Radiopedia(2015) http://radiopaedia.org/articles/optic-nerve-glioma Accessed on October 2 2015
- ↑ 2.0 2.1 Optic glioma. Medline Plus(2015) https://www.nlm.nih.gov/medlineplus/ency/article/001024.htm Accessed on October 5 2015
- ↑ Dutton JJ (1994). "Gliomas of the anterior visual pathway". Surv Ophthalmol. 38 (5): 427–52. PMID 8009427.
- ↑ Alvord EC, Lofton S (1988). "Gliomas of the optic nerve or chiasm. Outcome by patients' age, tumor site, and treatment". J Neurosurg. 68 (1): 85–98. doi:10.3171/jns.1988.68.1.0085. PMID 3275755.
- ↑ Nair AG, Pathak RS, Iyer VR, Gandhi RA (2014). "Optic nerve glioma: an update". Int Ophthalmol. 34 (4): 999–1005. doi:10.1007/s10792-014-9942-8. PMID 24736941.