Anaplastic large cell lymphoma medical therapy

	Anaplastic large cell lymphoma Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

**Treatment for anaplastic large cell lymphoma**
Type	Chemotherapy	Radiotherapy	Stem cell transplant	Surgery
Primary cutaneous anaplastic large cell lymphoma	Only used for people with extensive disease, where many areas of the skin are affected Used for people cannot be treated with localized treatment	External beam radiation therapy to the area (for localized disease)	--------	Surgery to remove the affected skin
Primary systemic anaplastic large cell lymphoma	Drug Regimen: (CHOP) Cyclophosphamide AND Doxorubicin AND Vincristine AND Prednisone	May be offered	May be offered	--------

Anaplastic large cell lymphoma usually responds well to chemotherapy, so it often has a good prognosis
It is treated with the same combinations of chemotherapy drugs used to treat other aggressive lymphomas
Drug Regimen: (CHOP) Cyclophosphamide AND Doxorubicin AND Vincristine AND Prednisone

When the lymphoma cells are only in one area of the lymph nodes (stage I primary systemic anaplastic large cell lymphoma)
For localized skin lesions in primary cutaneous anaplastic large cell lymphoma

A stem cell transplant may be offered to some people with anaplastic large cell lymphoma who relapse after initial treatment

Overall better prognosis than other "Aggressive Lymphomas"
- ALK+ 5-year survival 70-80%
- ALK- 5-year survival 30-40%