Burkitt's lymphoma medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive immunotherapy and stem cell transplantation may be required.

Medical Therapy

The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive immunotherapy and stem cell transplantation may be required.

Chemotherapy

• Chemotherapeutic regimens for Burkitt's lymphoma include:
• Cyclophosphamide AND Vincristine AND Doxorubicin AND Methotrexate (CODOX-M)
• Ifosfamide PLUS Mesna AND Etoposide AND Cytarabine (IVAC)
• Cyclophosphamide AND Vincristine AND Doxorubicin AND Dexamethasone AND Methotrexate AND Cytarabine (Hyper-CVAD)

CNS prophylaxis

• There is a high risk that Burkitt's lymphoma will spread to the central nervous system (CNS)
• CNS prophylaxis may involve giving intrathecal chemotherapy, high doses of systemic therapy, or both methods may be used
• Methotrexate and Cytarabine are the drugs used most often for CNS prophylaxis

Biological therapy

• Monoclonal antibodies are a type of biological therapy that is effective in treating Burkitt's lymphoma
• Rituximab may be added to each of the above chemotherapy regimens

Stem cell transplant

• A stem cell transplant may be offered to some people with Burkitt's lymphoma if their lymphoma returns or relapses after treatment

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