Thyroid adenoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Classification

• Thyroid adenomas are classified into 2 subtype: follicular adenoma and others.
• Others include papillary adenoma which is very rare. Almost all thyroid adenomas are follicular adenomas.
• Follicular adenomas can be described as "cold", "warm" or "hot" depending on their level of function.
• Histopathologically, follicular adenomas can be classified according to their cellular architecture and relative amounts of cellularity and colloid into the following types depicted in the flowchart.

Thyroid adenoma

Microfollicular adenoma (Fetal adenoma)

Macrofollicular adenoma (colloid adenoma)

Hürthle cell adenoma (oxyphil or oncocytic tumor)

Atypical embryonal adenoma

Hyalinizing trabecular adenoma

• Below is a table with the description of different types of follicular adenoma:

Number	Type of follicular adenoma	Description
1	Microfollicular adenoma (Fetal)	Consist of small, closely packed follicles lined with epithelium Have the potential for microinvasion
2	Macrofollicular adenoma (colloid adenoma)	Consists of large amount of colloid Do not have the potential for microinvasion
3	Hürthle cell adenoma (oxyphil or oncocytic tumor)	Consists of oxyphil cells Have the potential for microinvasion
4	Atypical embryonal adenoma	Consists of embryonic cells Have the potential for microinvasion
5	Hyalinizing trabecular adenoma	Consists of hyalinization Have the potential for microinvasion