Sandbox:classification 1

Hairy cell leukemia classification

Hairy cell leukemia

Hairy cell leukemia variant

Occurs in approximately 95% of the cases The male to female ratio is approximately 4 to 1 The median age at diagnosis is 55 years Less than 10% lymphocytosis on peripheral blood smear Decreased level of monocyte on peripheral blood smear Decreased hemoglobin level in approximately 85% of the patients Thrombocytopenia is present in approximately 80% of the patients CD103 +, CD11c +, CD25 + DBA.44 + Cyclin D1 + Annexin A1 + on immunohistochemistry Presence of BRAF V600E mutation on cytogenetic tests

Occurs in approximately 5% of the cases The male to female ratio is approximately 2 to 1 The median age at diagnosis is greater than 70 years. Less than 10% lymphocytosis on peripheral blood smear Normal level of monocyte on peripheral blood smear Normal hemoglobin level in most of the patients Normal platelets count in most of the patients CD103 +, CD11c +, CD25 - on immunophenotype DBA.44 + Cyclin D1 + Annexin A1 - on immunohistochemistry Presence of BRAF wild type on cytogenetic tests

The median age at diagnosis is 55 years.