| | | | | | | Hairy cell leukemia classification | | | | | | | | |
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| | | Hairy cell leukemia | | | | | | Hairy cell leukemia variant | | | | | | |
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- Occurs in approximately 95% of the cases
- The male to female ratio is approximately 4 to 1
- The median age at diagnosis is 55 years
- Less than 10% lymphocytosis on peripheral blood smear
- Decreased level of monocyte on peripheral blood smear
- Decreased hemoglobin level in approximately 85% of the patients
- Thrombocytopenia is present in approximately 80% of the patients
- CD103+, CD11c+, and CD25+ on immunophenotype
- DBA.44+, Cyclin D1+, and Annexin A1+ on immunohistochemistry
- Presence of BRAF V600E mutation on cytogenetic tests
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- Occurs in approximately 5% of the cases
- The male to female ratio is approximately 2 to 1
- The median age at diagnosis is greater than 70 years
- greater than 90% lymphocytosis on peripheral blood smear
- Normal level of monocyte on peripheral blood smear
- Normal hemoglobin level in most of the patients
- Normal platelets count in most of the patients
- CD103+, CD11c+, and CD25- on immunophenotype
- DBA.44+, Cyclin D1+, and Annexin A1- on immunohistochemistry
- Presence of BRAF wild type mutation on cytogenetic tests
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The median age at diagnosis is 55 years.