Sandbox: patho3

Genetics

• The most common gene involved in the pathogenesis of hairy cell leukemia is BRAF V600E mutations.
• The BRAF V600E mutations is present in all patients with hairy cell leukemia classic.
• The BRAF V600E mutations is not present in patients with hairy cell leukemia variant.
• Other genes involved in the pathogenesis of hairy cell leukemia include:

• Under expression of c

The cells underexpress 3p24, 3p21, 3q13.3-q22, 4p16, 11q23, 14q22-q24, 15q21-q22, 15q24-q25, and 17q22-q24 and overexpress 13q31 and Xq13.3-q21==Associated Conditions==