Oligoastrocytoma other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Other diagnostic studies for oligoastrocytoma include biopsy (homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo) and fluorescent in-situ hybridization (FISH) technique (deletions of chromosome 1p and 19q).^[1]

Biopsy may be performed to help confirm the diagnosis of oligoastrocytoma.
On biopsy, oligoastrocytoma is characterized by homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “fried egg” appearance.
Biopsy may be done at the time of surgical resection of oligoastrocytoma.
Biopsy may be of two types: open and stereotactic.
Indications for open biopsy and stereotactic biopsy are described below:^[2]


Type of biopsy	Indications

Open biopsy	Surgically resectable masses Lesions in accessible and relatively “silent” areas of the brain or in areas of the brain with a mild postoperative neurologic deficit Appearance consistent with tumor on the MRI Large tumors exerting mass effect
Stereotactic biopsy	Deep-seated tumor that is not amenable to resection Lesions in which the radiological and clinical findings are ambiguous Diffuse or multiple lesions Appearance that suggests a lymphoma, which would not require resection Change in the appearance of a previously diagnosed or treated tumor Assessment of tumor after treatment (to distinguish between radiation necrosis and tumor recurrence)