Renal oncocytoma pathophysiology

Renal oncocytoma Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

On gross pathology, tan or mahogany brown, well circumscribed, and central scar are characteristic findings of the tumor of renal oncocytoma.

Pathogenesis

• Renal oncocytoma is thought to arise from the intercalated cells of collecting ducts of the kidney.

Gross Pathology

• The tumors are tan or mahogany brown, well circumscribed and contain a central scar. They may achieve a large size (up to 12 cm in diameter).

Microscopic Pathology

• An epithelial tumor composed of oncocytes, large eosinophilic cells having small, round, benign-appearing nuclei with large nucleoli with excessive amounts of mitochondria.