Essential thrombocytosis history and symptoms
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Essential thrombocytosis Microchapters |
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Differentiating Essential thrombocytosis from other Diseases |
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Diagnosis |
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Treatment |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
History and symptoms
Patients with a mild form of disease are usually asymptomatic. Patients may have symptoms of minimal bleeding that went unnoticed until diagnosis. Most of the symptoms are vascular, either from thrombi occluding small and large blood vessels, though any blood vessel may be involved. Symptoms depend on the blood vessel occluded and include but are not limited to the following:
- Headache, dizziness
- Vision disturbances
- Chest pain
- Intense burning pain in hands or feet(erythromelalgia)
- Numbness and tingling of hands and feet
- Priapism
Although less common, bleeding can occur despite the increased platelet count accounting to the dysfunctional platelets. Common sites of bleeding include eyes, nose(epistaxis), gums, gastrointestinal tract, skin(bruises). The bleeding itself is usually minimal.
Bu using the platelet counts, severity of the disease can be assessed as follows:
- Mild- Platelet count>500,000μL - 700,000μL
- Moderate- Platelet count>700,000μL - 900,000μL
- Severe- Platelet count >900,000μL
- Extreme- Platelet count >1,000,000μL