Sandbox:DDx HEENT

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  • 30-50 yo Caucasian women
  • Ionizing radiation exposure
  • Positive family history
  • Asymptomatic painless neck nodule


Elevated thyroglobulin level HBME-1 stain +ve ATP5E stain +ve Orphan Annie eye nuclear inclusions Psammoma bodies

Unencapsulated Lymphatic spread Multifocal

RET proto-oncogene BRAF oncogene

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