Sandbox:DDx HEENT

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  • May have diarrhea, flushing, and pruritis
  • MEN2 (pheochromocytoma and hyperparathyroidism symptoms)
  • Thyroid nodule
  • Elevated calcitonin
  • Elevated chromogranin
  • Elevated CEA
  • Nested with delicate vascular septa pattern of growth
  • Polygonal cells, round nuclie with coarse chromatin, granular cytoplasm, surrounded by amyloid deposits
  • Vascular stroma with hemorrhage, edema, and coarse calcification
  • C-cell hyperplasia may be present


  • Neck lymphadenopathy
  • RET proto-oncogene
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