Mesoblastic nephroma pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
On gross pathology, a solid nonencapsulated mass that often occurs near the renal hilum is the characteristic finding of mesoblastic nephroma. On microscopic histopathological analysis, spindle cell is the characteristic finding of classic mesoblastic nephroma; whereas, plump cells with vesicular nuclei is the characteristic finding of cellular mesoblastic nephroma.
Gross Pathology
Characteristic findings of mesoblastic nephroma include:[1]
- Solid nonencapsulated mass
- Often occurs near the renal hilum
- Tends to invade the surrounding structures and renal parenchyma
- Hemorrhage and necrosis are infrequent
Microscopic Pathology
Classic mesoblastic nephroma[2]
- Spindle cells in fascicles
- Infiltrative border
Cellular mesoblastic nephroma
- Plump cells with vesicular nuclei
- Well-defined border
- Mitotically active
Mixed mesoblastic nephroma
- Both classic pattern and cellular pattern areas are present
Genetics
Translocation t(12:15)(p13;q25) that generates the genetic fusion of ETV6/NTRK3 gene is involved in the pathogenesis of mesoblastic nephroma.[3]
References
- ↑ Mesoblastic nephroma.Dr Ayush Goel and Dr Yuranga Weerakkody et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/mesoblastic-nephroma
- ↑ Humphrey, Peter (2008). The Washington manual of surgical pathology. Philadelphia: Lippincott Williams & Wilkins. ISBN 978-0781765275.
- ↑ Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH (1998). "A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma". Nature Genetics. 18 (2): 184–7. doi:10.1038/ng0298-184. PMID 9462753.