Waldenström's macroglobulinemia pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Pathogenesis

It is due to the effects of the IgM paraprotein, which may cause autoimmune phenomenon or cryoglobulinemia. Other symptoms of WM are due to the hyperviscosity syndrome, which is present in 6-20% of patients.This is attributed to the IgM monoclonal protein increasing the viscosity of the blood.