Sandbox:DDx HEENT

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  • 4-7 yo males
  • Abdominal pain, constipation, abdominal distension
  • Positive history of EBV or HIV infection


  • Jaw or submaxillary swelling
  • Erythema and ulceration of overlying skin
  • Sheets of a monotonous lymphoid cells, basophilic cytoplasm, four small nucleoli.
  • High proliferative and apoptotic activity
  • scattered tingible body-laden macrophage
  • "starry sky"appearance
  • CD19, CD20, CD22, CD79a)
  • t(8;14)(q24;q32)
  • c-myc gene disregulation
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