Waldenström's macroglobulinemia
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Waldenström's macroglobulinemia Microchapters |
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Differentiating Waldenström's macroglobulinemia from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Waldenström's macroglobulinemia On the Web |
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American Roentgen Ray Society Images of Waldenström's macroglobulinemia |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mirdula Sharma, MBBS [2]
Synonyms and keywords: Primary macroglobulinemia; B-cell lymphoproliferative disease; Lymphoplasmacytoid lymphoma, Lymphoplasmacytoid Lymphomas; Macroglobulinemia; Plasmacytoid lymphocytic lymphoma; Familial Waldenstrom's Macroglobulinaemia; Familial Waldenstrom Macroglobulinaemia
Overview
Historical Perspective
Classification
The World Health Organization placed Waldenström's macroglobulinemia under the category of lymphoplasmacytic lymphomas, which is a subcategory of low-grade Non-Hodgkin lymphoma.[1]
Pathophysiology
Causes
- The most common causes are a somatic mutation in MYD88 (90% of patients) and a somatic mutation in CXCR4 (27% of patients).[1]
Differentiating Waldenström's macroglobulinemia from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms | Physical Examination | Laboratory Findings | Bone Marrow Aspiration and Biopsy | Electrophoresis and Immunofixation | Chest X Ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies
Treatment
Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies
Case Studies