Essential thrombocytosis laboratory findings
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Essential thrombocytosis Microchapters |
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Differentiating Essential thrombocytosis from other Diseases |
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Diagnosis |
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Treatment |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Lab tests for the diagnosis of Essential thrombocytosis include tests to rule out reactive or secondary causes of thrombocytosis and ET remains a diagnosis of exclusion. The tests include abnormal complete blood count (CBC), peripheral blood smear, cytogenetic studies including Philadelphia chromosome or BCR-ABL assay, and the presence of JAK2 V617F mutations. Bone marrow biopsy is an important test and needed to make a diagnosis of ET.[1]
Laboratory findings
Lab tests for the diagnosis of Essential thrombocytosis include the following[2]:
- Complete blood count (CBC)
- Elevated platelet count
- Leukocytosis, erythrocytosis, and mild anemia may be present
- Peripheral blood smear shows large platelets
- Platelet aggregation studies may be abnormal in some patients
References
- ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID http://dx.doi.org/10.1182/blood-2007-04-083501 Check
|pmid=value (help). - ↑ Essential Thrombocytosis Workup. Medscape. http://emedicine.medscape.com/article/206697-workup#c8. Accessed on November 10th, 2015