Waldenström's macroglobulinemia history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
|
Waldenström's macroglobulinemia Microchapters |
|
Differentiating Waldenström's macroglobulinemia from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Waldenström's macroglobulinemia history and symptoms On the Web |
|
American Roentgen Ray Society Images of Waldenström's macroglobulinemia history and symptoms |
|
Waldenström's macroglobulinemia history and symptoms in the news |
|
Blogs on Waldenström's macroglobulinemia history and symptoms |
|
Directions to Hospitals Treating Waldenström's macroglobulinemia |
|
Risk calculators and risk factors for Waldenström's macroglobulinemia history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]
Overview
History and Symptoms
Asymptomatic or Smoldering:
Presents in 30% of patients with Waldenström's macroglobulinemia.[1]
Symptomatic:
Constitutional symptoms
- Weight loss[1]
- Fever
- Night sweat
- Lymphedema
Hyperviscosity syndrome
Accumulation of IgM proteins in blood can increase the viscosity of blood, slowing down the flow of blood to different organs. Symptoms of hyperviscosity include:[1]
- Retinal hemorrhage with blurring of vision problem
- Vertigo
- Dizziness
- Headache
- Oronasal bleeding
Bone marrow infiltration
- Anemia[2]
- Pancytopenia
References:
- ↑ 1.0 1.1 1.2 Waldenström's macroglobulinemia symptoms and signs. Cancer.Net (2015)http://www.cancer.net/cancer-types/waldenstrom’s-macroglobulinemia/symptoms-and-signs Accessed on November 10, 2015
- ↑ Monge J, Braggio E, Ansell SM (2013). "Genetic factors and pathogenesis of Waldenström's macroglobulinemia". Curr Oncol Rep. 15 (5): 450–6. doi:10.1007/s11912-013-0331-7. PMC 3807757. PMID 23901022.
History and Symptoms
Patients with WM may present with various symptoms.[1]
- Approximately 30% of the patients are asymptomatic (smoldering WM).
- Anemia with mean hemoglobin less than 10 g/dL - fatigue
- Bone marrow infiltration: cause anemia & pancytopenia
- Extramedullary infiltration - hepatomegaly, splenomegaly, lymphadenopathy
- Hyperviscosity - oronasal bleeding, retinal hemorrhage with blurring or loss of vision, headache, vertigo, ataxia
- IgM monoclonal proteins - peripheral neuropathy
References
- ↑ Monge J, Braggio E, Ansell SM (2013). "Genetic factors and pathogenesis of Waldenström's macroglobulinemia". Curr Oncol Rep. 15 (5): 450–6. doi:10.1007/s11912-013-0331-7. PMC 3807757. PMID 23901022.