Hepatic hemangioma pathophysiology

Hepatic hemangioma Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]

Overview

They arise from the endothelial cells that line the blood vessels and consists of multiple, large vascular channels lined by a single layer of endothelial cells and supported by collagenous walls.

Pathogenesis

• They arise from the endothelial cells that line the blood vessels and consists of multiple, large vascular channels lined by a single layer of endothelial cells and supported by collagenous walls.
• They may be associated with focal nodular hyperplasia.

Associated Conditions

Hepatic hemangioma may be associated with:

• Kasabach-Merritt syndrome
• Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease)
• Hepatic arterio-portal shunts
• Extra hepatic hemangiomata
• Hemolytic anemia
• Consumptive coagulopathy

Gross Pathology

On gross pathology, variable in size, well circumscribed, classically subcapsular are characteristic findings of hepatic hemangioma.

Microscopic Pathology

On microscopic histopathological analysis channels lined by benign endothelium containing RBCs, surrounding (non-endothelial) cells without significant atypia are characteristic findings of hepatic hemangioma.

Gallery

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  Intermediate magnification micrograph of a cavernous hemangioma of the liver, also hepatic cavernous hemangioma, liver hemangioma,cavernous liver hemangioma. H&E stain. No liver tissue is observed.

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  High magnification micrograph of a cavernous hemangioma of the liver, also hepatic cavernous hemangioma, liver hemangioma,cavernous liver hemangioma. H&E stain. No liver tissue is observed.